Differential Diagnosis in Dermatopathology

Scleroderma (morphea) vs. Scleredema (Buschke)

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Differential Diagnosis in Dermatopathology

Images

Angiolymphoid hyperplasia with eosinophilia Kimura’s disease…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic erythema of the newborn

…ts infundibular epidermis. Laboratory confirmation Peripheral eosinophilia sometimes is present. Cause and mechanism Both are unknown. Comment The name “toxic erythema of the newborn” fails to communicate anything about the nature fundame…

Differential Diagnosis in Dermatopathology

Discussions

…widespread, the condition has been designated fasciitis with eosinophilia (eosinophilic fasciitis) or Shulman’s syndrome. Whether morphea consists of a single lesion or many of them and whether it involves the upper part of the dermis (lichen…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

…1-24. Cobane JH, Straith CL, Pinkus H. Facial granulomas with eosinophilia: their relation to other eosinophilic granulomas of the skin and to reticulogranuloma. Arch Dermatol 1950;60:442. Cribier B, Couilliet D, Meyer P, Grosshans E. The severity of…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Angiolymphoid hyperplasia with eosinophilia Angiosarcoma 1. Dome-shaped papules, nodules, and tumors 1. Patch or plaque usually 2. Ulceration rare 2. Ulceration common 3. Well circumscribed lesion composed of relatively few thick-walled bloo…

Histologic Diagnosis of Inflammatory Skin Diseases

Parasitic infestations

…e parasite is demonstrated in tissues or in blood. Peripheral eosinophilia is present. Cause and mechanism Various distinctive parasites are causative. Comment Most infestations in the skin by parasites occur by accident, being transferred there fro…