Differential Diagnosis in Dermatopathology

Scleroderma (morphea) vs. Scleredema (Buschke)

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Differential Diagnosis in Dermatopathology

Images

Angiolymphoid hyperplasia with eosinophilia Kimura’s disease…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic erythema of the newborn

Toxic erythema of the newborn Synonyms Erythema neonatorum Erythema toxicum Erythema neonatorum allergicum Presentation stereotypical Age and sex Neonates during the first few days of life Distribution of lesions Widespread Arrangement of lesions Sc…

Differential Diagnosis in Dermatopathology

Discussions

A major source of confusion in differentiation of scleroderma and scleredema is terminology, the names of the wholly dissimilar conditions being so similar. Moreover, both diseases are associated with alterations of collagen in the dermis. The impor…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

Leukocytoclastic vasculitis Synonyms Leukocytoclastic angiitis Allergic vasculitis Hypersensitivity angiitis Hypersensitivity vasculitis Anaphylactoid purpura Immune complex vasculitis Purpura rheumatica Presentation stereotypical Age and sex Any ag…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Angiolymphoid hyperplasia with eosinophilia Angiosarcoma 1. Dome-shaped papules, nodules, and tumors 1. Patch or plaque usually 2. Ulceration rare 2. Ulceration common 3. Well circumscribed lesion composed of relatively few thick-walled bloo…

Histologic Diagnosis of Inflammatory Skin Diseases

Parasitic infestations

Parasitic infestations Presentation stereotypical Age and sex No predilection for age or sex; occurring chiefly in the tropics Distribution of lesions Localized usually to one site anatomic; some infestations parasitic are associated with lesions wi…