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Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ixed-cell + 10.28.1B: Scant infiltrate of neutrophils and eosinophils in the subepidermal space = Epidermolysis bullosa, recessive dystrophic The specimen can be told to have come from a child because the dermis is thin and epithelial structures…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…them in clusters, in the epidermis and the presence often of eosinophils and sometimes plasma cells in the infiltrate are distinguishing. Lichenoid photodermatitis displays a basket-weave pattern of the cornified layer and absence of hypergranulosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Interstitial granulomatous dermatitis with arthritis

…us fat Some histiocytes with large nuclei and some in mitosis Eosinophils and neutrophils in number variable scattered throughout the infiltrate of histiocytes In foci, degeneration of a few collagen bundles surrounded by histiocytes arrayed in a pal…

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…nd others reminiscent of coffee beans. Numerous intermingling eosinophils were present. The diagnosis of Langerhans cell histiocytosis was then rendered and confirmed by positive immunostaining of neoplastic cells for anti-CD1a and anti-S100 protein…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…10.107.1B: An infiltrate of lymphocytes, neutrophils, and eosinophils, marked edema of the papillary dermis, and ballooned and necrotic keratocytes = Toxic shock syndrome Because of edema in the upper part of the dermis and of spongiosis, this le…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatitis herpetiformis

…usters of neutrophils in conjunction with fibrin Few, if any, eosinophils in the upper part of the dermis Fully developed Same findings as in early lesion plus Subepidermal blister that houses neutrophils and, usually, eosinophils Acantholytic cell…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…pigmentosa  Spongiosis is mediated commonly by lymphocytes or eosinophils. In prurigo pigmentosa, spongiosis is present early in the process and it is mediated mostly by neutrophils. 10.88.5A: Perivascular dermatitis, spongiotic + 10.88.5B:…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s + 10.52.1B: Lymphocytes, plasma cells, neutrophils, and eosinophils in company with fibrocytes and histiocytes, the latter being predominant = Interstitial granulomatous dermatitis with arthritis Some histiocytes have abnormal nuclei and some o…

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