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Histologic Diagnosis of Inflammatory Skin Diseases

Images

…l cells suggest that at least some of it may have begun in the epidermis. 10.11.4A: Vesicular dermatitis, intra- and subepidermal, with confluent epidermal necrosis + 10.11.4B: Necrosis of infundibular epidermis and a scant infiltrate of ne…

Histologic Diagnosis of Inflammatory Skin Diseases

Nail Units

…ehind, and under the nail to the distal edge, they are (1) the epidermis of the proximal nail fold, (2) the epithelium of the nail matrix, (3) the epithelium of the nail bed, (4) the epidermis of the hyponychium, and (5) the epidermis of volar skin o…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Spongiform Pustular Diseases?

…stage in migration of neutrophils from the dermis through the epidermis, a spongiform pustule may occupy not only the spinous zone, but the granular zone and the cornified layer, too, and not only of the surface epidermis, but also of infundibular e…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…eratocytes that range from few to many in the suprabasal space Epidermis above suprabasal clefts and blisters mostly intact Late Sparse to moderately dense perivascular and interstitial mixed-cell infiltrate Erosion often Re-epithelialization of ep…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…he periphery of the lesion Hyperpigmentation of the acanthotic epidermis usual Induction of folliculosebaceous units from surface epidermis by follicular papilla-like structures sometimes Foam cells at times in the subcutaneous fat Late Fibrocytes…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…c cells amid neutrophils in a blister in the lower part of the epidermis and in an eccrine duct = Pemphigus vulgaris, fully developed ┬áThe findings illustrate the role neutrophils also play in mediating development of acantholytic cells in the epider…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

Fixed drug eruption Synonyms Fixed toxic exanthem Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Lips, genital region, and limbs especially Configuration of lesions Round Arrangement of lesions Solitary or few, d…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.45.1A: Vesicular dermatitis, intraepidermal, acantholytic + 10.45.1B: Suprabasal separation with acantholytic dyskeratotic cells throughout most of the thickness of the thickened epidermis = Hailey-Hailey disease Because when th…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…fundibula and dermis, as well as along the junction of surface epidermis and dermis; subepidermal vesiculation uncommon Necrotic keratocytes disposed as solitary units positioned in the lower portion of the epidermis mostly and often in infundibula S…

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