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Histologic Diagnosis of Inflammatory Skin Diseases

Images

…: Lymphocytes, jagged acanthosis, necrotic keratocytes in the epidermis, a thick granular layer, and mostly compact orthokeratosis = Lichen planus-like keratosis, fully developed  Episodically, lichen planus-like keratosis is biopsied by punch techni…

Histologic Diagnosis of Inflammatory Skin Diseases

Nail Units

…hind, and under the nail to the distal edge, they are (1) the epidermis of the proximal nail fold, (2) the epithelium of the nail matrix, (3) the epithelium of the nail bed, (4) the epidermis of the hyponychium, and (5) the epidermis of volar skin of…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s a first-degree burn because the changes are confined to the epidermis. That the lesion developed rapidly may be inferred from the presence still of a normal stratum corneum marked by a basket-weave configuration of corneocytes. The blister as it ap…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…oles between cells in the basal layer and spinous zone of the epidermis (surface and infundibular) and of epithelial structures of adnexa Incipient acantholysis in the lower part of the spinous zone Fully developed Sparse superficial perivascular a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Spongiform Pustular Diseases?

…is composed of leukocytes that have migrated into the soaked epidermis, destroying epithelial cells by invading them or going between them.” Kogoj F. Die spungiforme (schwammartige) Pustel. Dermatol Wochnschr 1938;107:1485-87. “Of all…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…a thickened basement membrane seated immediately beneath the epidermis) and, having made those observations, proceeds to employ an algorithm that leads directly to what is hoped will be an accurate, specific diagnosis couched in language comprehensi…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…the lesion Acanthosis and hyperpigmentation of the thickened epidermis often Fully developed Dense diffuse infiltrate composed both of histiocytes, some of which may be siderophages and/or lipophages, and fibrocytes in a nodule in the reticular de…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…me into being in the absence of any inflammatory cells in the epidermis. An exception is the urticarial manifestation of the disease; spongiosis in that circumstance is accompanied by eosinophils or neutrophils, the latter being pictured here. These…

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