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Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.11.1A: Perivascular dermatosis, lichenoid + 11.11.1B: Lymphocytes, many necrotic keratocytes and a subepidermal cleft = Lichen planus-like keratosis, early ┬áBecause lichen planus-like keratosis often is misinterpreted clinically…

Histologic Diagnosis of Inflammatory Skin Diseases

Nail Units

…ehind, and under the nail to the distal edge, they are (1) the epidermis of the proximal nail fold, (2) the epithelium of the nail matrix, (3) the epithelium of the nail bed, (4) the epidermis of the hyponychium, and (5) the epidermis of volar skin o…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…l cells suggest that at least some of it may have begun in the epidermis. 10.11.4A: Vesicular dermatitis, intra- and subepidermal, with confluent epidermal necrosis + 10.11.4B: Necrosis of infundibular epidermis and a scant infiltrate of ne…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…eratocytes that range from few to many in the suprabasal space Epidermis above suprabasal clefts and blisters mostly intact Late Sparse to moderately dense perivascular and interstitial mixed-cell infiltrate Erosion often Re-epithelialization of ep…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Spongiform Pustular Diseases?

…stage in migration of neutrophils from the dermis through the epidermis, a spongiform pustule may occupy not only the spinous zone, but the granular zone and the cornified layer, too, and not only of the surface epidermis, but also of infundibular e…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…dibulum is epithelial, being as it is as much a constituent of epidermis as is surface epidermis. Pustular dermatitides, therefore, can be divided rationally into those of infundibular epidermis (e.g., pustules of acne vulgaris, rosacea, and halogeno…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…he periphery of the lesion Hyperpigmentation of the acanthotic epidermis usual Induction of folliculosebaceous units from surface epidermis by follicular papilla-like structures sometimes Foam cells at times in the subcutaneous fat Late Fibrocytes…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…c cells amid neutrophils in a blister in the lower part of the epidermis and in an eccrine duct = Pemphigus vulgaris, fully developed ┬áThe findings illustrate the role neutrophils also play in mediating development of acantholytic cells in the epider…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.45.1A: Vesicular dermatitis, intraepidermal, acantholytic + 10.45.1B: Suprabasal separation with acantholytic dyskeratotic cells throughout most of the thickness of the thickened epidermis = Hailey-Hailey disease Because when th…

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