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Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.8.1A: Perivascular and interstitial dermatitis + 10.8.1B: Large numbers of neutrophils scattered interstitially in association with degeneration of collagen = Behçet’s disease Dense infiltrates of neutrophils in the dermis…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.99.1A: Vasculitis, small vessel, neutrophilic; panniculitis, lobular; perivascular and interstitial dermatitis, and vesicular dermatitis, subepidermal + 10.99.1B: Thrombi in the lumen of venules and countless bacteria in the int…

Histologic Diagnosis of Inflammatory Skin Diseases

Cat-scratch disease

Cat-scratch disease Presentation stereotypical Age and sex Any age and either sex, but children and young adults preponderantly Distribution of lesions Localized at the site of a scratch or a bite by a cat Individual lesions Papules, pustules, or cr…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.7.1A: Diffuse dermatitis, mixed-cell + 10.7.1B: Proliferation of venules lined by plump endothelial cells, a sprinkling of neutrophils and nuclear “dust” of neutrophils, and clumps of granular violaceous mate…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

Arthropod assaults Synonyms Insect “bite” Bug bite Insect bite reaction Papular urticaria Lichen urticatus Strophulus Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions At times only a single lesion a…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

Necrobiosis lipoidica Synonyms Necrobiosis lipoidica diabeticorum Dermatitis atrophicans lipoidica diabetica Necrobiosis lipoidica granulomatosis Granulomatous tuberculoides pseudosclerodermiformis of Gottron Granulomatous disciformis chronica et pr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Capillaritis?

“Pigmented purpuric eruptions. Under this term, three diseases are listed. It is doubtful that the division is warranted, since the most recent studies would suggest that these three divisions are each a phase or type of chronic capillaritis…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.28.1A: Vesicular dermatitis, subepidermal, mixed-cell + 10.28.1B: Scant infiltrate of neutrophils and eosinophils in the subepidermal space = Epidermolysis bullosa, recessive dystrophic The specimen can be told to have come from…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Chondrodermatitis Nodularis Helicis?

“At the dermatology meeting in Berlin, Jadassohn also indicated that changes in the cartilage can often be established clinically, especially the knobby sites on the helix that show a whitish transparence through a thinned epidermis. My expe…

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