Search Results for: fibrin

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Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…of the body to external trauma. When, as a response to injury, activation of the coagulation cascade results in formation of fibrin, which then casts a net at the surface of a wound, platelets attach to that network, thereby contributing to closure…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…et’s disease, this is not leukocytoclastic vasculitis because thrombi are present in the lumen of venules, rather than fibrin in the wall of them. 10.8.3A: Vesicular dermatitis, intraepidermal, ballooned + 10.8.3B: Neutrophils and eosinophils…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…reticular alteration + 10.99.5C + 10.99.5D = Septic vasculitis Unlike the situation in leukocytoclastic vasculitis in which fibrin is present in the wall of venules, in septic vasculitis thrombi are present in lumen of them. That occlusion results…

Histologic Diagnosis of Inflammatory Skin Diseases

Cat-scratch disease

…gal infection is characterized often by prominent scale-crust. Findings histopathologic Fully developed Zone of necrosis and fibrin in the upper part of the reticular dermis surrounded by a mantle of macrophages, lymphocytes, and plasma cells…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…iad bacteria of Bartonella species. 10.7.4A: Nodular dermatitis + 10.7.4B: Lymphocytes, plasma cells, histiocytes, necrosis, fibrin, fragments of necrotic inflammatory cells and pseudocarcinomatous (infundibular) proliferation + 10.7.4C + 10.7.4D =…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…accompanied, episodically, by signs of vasculitis, usually in the form of thrombi in the lumen of venules, but sometimes of fibrin deposited in the wall of venules. Findings of small-vessel vasculitis are seen in less than 15% of all biopsy…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Capillaritis?

…named for Schamberg, Gougerot and Blum, Doucas and Kapetanakis, are not vasculitides. None of them is associated with either fibrin in the wall of venules or thrombi in the lumen of them. The denominators in common of those diseases are infiltrates…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…four diseases. In the center of a palisade of histiocytes of granuloma annulare are found degeneration of collagen, a tad of fibrin, and abundant mucin; in that of necrobiosis lipoidica, abundant degenerated collagen in early lesions and crowded…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…28.4A: Vesicular dermatitis, subepidermal, mixed-cell + 10.28.4B: Neutrophils, eosinophils, and lymphocytes, in company with fibrin, in the subepidermal blister = Acquired epidermolysis bullosa Changes like those pictured do not conform to one of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…t includes “necrosis of collagen,” “necrobiotic collagen bundles,” and “basophilic necrotizing fibrinoid material.” It is reasonable, therefore, to forego the notion of a Churg-Strauss granuloma and employ instead…

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