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Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…itchy by virtue of the effects of neutrophils spewed from an infundibulum on nerve endings, the situation occurring mostly in patients on renal dialysis and in some with diabetes, the latter being the circumstance of the patients reported on origina…

Histologic Diagnosis of Inflammatory Skin Diseases

Acne vulgaris

…copathologic A comedo is a plug of orthokeratotic cells in an infundibulum dilated considerably by it. A skin-colored papule is a milium, i.e., a tiny infundibular cyst, and a red papule is a comedo or a milium that has ruptured and spewed its conten…

Histologic Diagnosis of Inflammatory Skin Diseases

Infundibulofolliculitis, disseminate and recurrent

…ed at the site where an apocrine duct is presumed to enter an infundibulum plugged by cornified cells. Some lesions exhibit coronoid lamellation in infundibula and foamy histiocytes around them. The process usually is confined to axillae. Atopic derm…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…221; of nuclear chromatin and multinucleate corneocytes in an infundibulum = Infection by herpesvirus, early If a microscopist fails to take note of the subtle changes in the infundibulum shown here, the diagnosis of herpesvirus will be missed. Not u…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Tricho-, pilo-, folliculo- ?

…; later the same process is called trichodiscoma. Although an infundibulum of epidermis is positioned in the center of each segment of fibrofolliculoma, the condition actually is an abnormality of mantles of a follicle, those distinctive cords of und…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

…being an infundibular cyst, a true epidermal cyst because the infundibulum is as much epidermis as is surface epidermis. The epithelium that lines virtually all other cutaneous cysts is like that of adnexal epithelium, namely, follicular, sebaceous,…

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

…in which the plug of corneocytes may penetrate the wall of an infundibulum and, as a consequence, call forth neutrophils followed by lymphocytes and, sometimes, histiocytes and later fibrocytes. A caricature of that phenomenon is what follows on rupt…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Common Baldness—an Inflammatory Disease?

…erate inflammatory infiltrate at the level of the isthmus and infundibulum. This can also be seen in scalp biopsies from normal patients or those with seborrheic dermatitis. We could not detect obvious inflammation in the lower portion of deeply seat…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…epithelioid histiocytes = Rosacea, papular ¬†Spongiosis in an infundibulum is a finding common in rosacea and in analogues of it, to wit, perioral and periocular dermatitis. 10.94.2A: Peri-infundibulitis, suppurative granulomatous + 10.94.2…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…s said to result from extrusion of contents suppurative of an infundibulum into the dermis. When the term was introduced, proponents of it contended that the condition was different from conventional suppurative folliculitides when, in actuality, vir…

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