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Differential Diagnosis in Dermatopathology

Mycosis fungoides, plaque vs. Histiocytosis X, plaque

A proliferation of abnormal Langerhanscells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…r bridges, the relatively few lymphocytes, and the addition of Langerhanscells. Granuloma annulare, interstitial type is distinguished from interstitial mycosis fungoides by lack of lymphocytes in foci in the interstitium of the reticular der…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…220;Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, role in…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…implications for the clinician. Eur J Dermatol 1999;9:241-251. Langerhanscells Romani N, Holzmann S, Tripp CH, Koch F, Stoitzner P. Langerhans cells—dendritic cells of the epidermis. APMIS 2003;111:725-740. Strobl H. Molecular mechanisms of d…

Histologic Diagnosis of Inflammatory Skin Diseases

Eccrine Units

…raverses the dermis. The coiled gland is formed of two rows of cells (Fig. 1.57), namely, (1) a discontinuous outer row of spindle-shaped, contractile myoepithelial cells and (2) an inner row of pyramidal, secretory epithelial cells. The single inner…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…nvolutional stage of a repeatable cycle in which numerous dead cells appear as solitary units in the lower segment of the follicle, at first in the bulb and, in a short time, the stem. As a consequence of the death of those epithelial cells, the bulb…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…1990;86:1783-1789. Lambert RW, Granstein RD. Neuropeptides and Langerhans cells. Exp Dermatol 1998;7:73-80. Luo M, Lee S, Brock TG. Leukotriene synthesis by epithelial cells. Histol Histopathol 2003;18:587-595. Madri JA, Graesser D. Cell migration in…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…sia but, at times, also by siderophages, “monster” cells, and epidermal hyperpigmentation. Histiocytosis X consists of large cells with reniform nuclei and abundant amphophilic cytoplasm (i.e., abnormal Langerhanscells) that rarel…

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