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Histologic Diagnosis of Inflammatory Skin Diseases

Cat-scratch disease

Cat-scratch disease Presentation stereotypical Age and sex Any age and either sex, but children and young adults preponderantly Distribution of lesions Localized at the site of a scratch or a bite by a cat Individual lesions Papules, pustules, or cr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…ng from pityriasis lichenoides chronica, which is primarily a disease of the epidermis…Very important and never described previously in this disease is the invasion of the vessel walls by lymphocytes. In addition, the endothelial cells are swol…

Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

Crohn’s disease Synonyms Inflammatory bowel disease Regional ileitis Regional enteritis Chronic cicatrizing enteritis Presentation stereotypical Age and sex Young adults; slight predominance of women Distribution of lesions The poles of the ga…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

Kimura’s disease Synonyms Eosinophilic lymphofolliculitis Presentation stereotypical Age and sex Young men, especially Asians Distribution of lesions Head, neck, and trunk Individual lesions Firm nodules and tumors, some gigantic, above which…

Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

Destombes-Rosai-Dorfman disease Synonyms Rosai-Dorfman disease Rosai-Dorfman histiocytosis Sinus histiocytosis with massive lymphadenopathy Presentation stereotypical Age and sex Usually in males under 25 years of age Distribution of lesions Localiz…

Differential Diagnosis in Dermatopathology

Pemphigus vulgaris vs. Grover’s disease, pemphigus vulgaris-like

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Differential Diagnosis in Dermatopathology

Solar keratosis vs. Bowen’s disease

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Histologic Diagnosis of Inflammatory Skin Diseases

Fox-Fordyce disease

Fox-Fordyce disease Synonyms Apocrine miliaria Presentation stereotypical Age and sex Postpubertal women mostly Distribution of lesions Sites where apocrine glands are numerous, i.e., axillae, periumbilical, pubic, and areolae Arrangement of lesions…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

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