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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…ing from pityriasis lichenoides chronica, which is primarily a disease of the epidermis…Very important and never described previously in this disease is the invasion of the vessel walls by lymphocytes. In addition, the endothelial cells are swo…

Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

Crohn’s disease Synonyms Inflammatory bowel disease Regional ileitis Regional enteritis Chronic cicatrizing enteritis Presentation stereotypical Age and sex Young adults; slight predominance of women Distribution of lesions The poles of the ga…

Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

Destombes-Rosai-Dorfman disease Synonyms Rosai-Dorfman disease Rosai-Dorfman histiocytosis Sinus histiocytosis with massive lymphadenopathy Presentation stereotypical Age and sex Usually in males under 25 years of age Distribution of lesions Localiz…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

…other pathologic processes, such as the singular inflammatory disease known for Kimura. Bibliography Bibliography for Kimura’s disease Arshad AR. Kimura’s disease of parotid gland presenting as solitary parotid swelling. Head Neck 2003;2…

Differential Diagnosis in Dermatopathology

Solar keratosis vs. Bowen’s disease

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Differential Diagnosis in Dermatopathology

Pemphigus vulgaris vs. Grover’s disease, pemphigus vulgaris-like

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Histologic Diagnosis of Inflammatory Skin Diseases

Fox-Fordyce disease

…ly, perioral and periocular dermatitis, but those inflammatory diseases are unaffiliated with infundibular plugs of corneocytes encountered usually in Fox-Fordyce disease. Disseminate and recurrent infundibulofolliculitis also may display spongiosis…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

…do those in the skin. That principle applies to virtually all diseases that affect both skin and mucous membranes, e.g., erythema multiforme, fixed drug eruption, lichen planus, cicatricial pemphigoid, and pemphigus vulgaris. In the case of diseases…

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