Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cutaneous T-cell Lymphoma?

…oma sometimes involves the skin as does adult T-cell lymphoma/leukemia. Uncommonly, Hodgkin’s disease is an expression of a T-cell, rather than of a B-cell, lymphoma, and rarely it may appear in the skin. In that circumstance, it also qualifies…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…ost disease   Barnes DWH, Loutit JF. Treatment of murine leukemia with x-rays and homologous bone marrow: II. Br J Haematol 1957; 241-52. Billingham RE. The biology of graft-versus-host reactions. Harvey Lect 1966-1967;62:21. Billingham RE, Bren…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

…ry diseases are lymphomatoid papulosis, adult T-cell lymphoma/leukemia, some B-cell and T-cell lymphomas situated entirely in the dermis and/or subcutaneous fat, and leukemias, especially the chronic lymphocytic type. Sixth, diseases whose nosologic…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Parapsoriasis?

…th pityriasis lichenoides exists.” Lynch PJ. Lymphoma, leukemia, and related diseases. In: Sams WM Jr, Lynch PJ, eds. Principles and Practice of Dermatology, 2nd ed. New York: Churchill Livingstone, 1996:303. “Classic cutaneous T cell…

Dermatology Practical & Conceptual

Dermatoscopy: What is your diagnosis?

Quiz A 61-year-old patient with chronic myelomonocytic leukemia presented with a red-to-brown maculopapular rash on the back (Figure 1). Some of the papular lesions seemed to be different from the other lesions (Figures 2, 3) and had a particular de…

Histologic Diagnosis of Inflammatory Skin Diseases

Polymorphous light eruption

…drome, pyoderma gangrenosum, erysipelas, and an expression of leukemia cutis, and some manifestations of spongiotic vesicular dermatitides, such as those caused by allergic contactants and by dermatophytes. In sum, a particular picture histopathologi…

Dermatology Practical & Conceptual

Uncommon presentations of tinea versicolor

…omised from chemotherapeutic treatment of acute lymphoblastic leukemia. Although uncommon, eruptions confined to the areola and periareolar areas have also been noted. Two patients had bilateral involvement of the areolae—one case occurred in a pubes…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Mycosis fungoides, papular/plaque stage Adult T-cell leukemia/lymphoma, papular stage 1. No crusts as a rule 1. Crusts common 2. No collections of lymphocytes in the cornified layer usually 2. Collections of lymphocytes in the cornified layer…