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Histologic Diagnosis of Inflammatory Skin Diseases

Images

…this one. 10.25.2A: Perivascular dermatitis, interface, lichenoid + 10.25.2B: A few eosinophils in an infiltrate of lymphocytes mostly = Drug eruption The presence of eosinophils in a lesion that otherwise is indistinguishable histopatholog…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Overlap Syndromes?

…ematosus and lichen planus, the lesions actually are those of lichenoid discoid lupus erythematosus; the lichenoid infiltrate of lymphocytes, the jagged hyperplasia of the epidermis, and the hyperkeratosis merely resemble findings in lichen planus. I…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…dermis, and a sparse infiltrate of lymphocytes, rather than a lichenoid one, along the dermoepidermal interface. 10.66.4A: Perivascular dermatitis, interface, vacuolar + 10.66.4B: Lymphocytes along the dermoepidermal junction, vacuolar alte…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ia. Traction alopecia is an inflammatory disease; it exhibits lichenoid peri-infundibulitis and perifolliculitis “early” in its course; trichotillomania, by contrast, is not an inflammatory disease. 10.108.2A: Section of a biopsy sp…

Differential Diagnosis in Dermatopathology

Lichen planus vs. Lichen planus-like keratosis

A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a syst…

Differential Diagnosis in Dermatopathology

Discussions

…tensibly, both are superficial perivascular dermatitides with lichenoid infiltrates made up mostly of lymphocytes that obscure the dermoepidermal junction where there are vacuolar alteration and necrotic keratocytes (interface dermatitis, lichenoid t…

Histologic Diagnosis of Inflammatory Skin Diseases

Persistent light reaction

…Moderately dense superficial and deep perivascular and patchy lichenoid infiltrate of lymphocytes, plasma cells, and eosinophils; some lymphocytes may be larger than normal Papillary dermis thickened also by coarse bundles of collagen disposed in ver…

Differential Diagnosis in Dermatopathology

Discussions

Lichen planus and lichenoid discoid lupus erythematosus have many findings histopathologic in common, among them hyperkeratosis of surface epidermis and plugs of cornified cells in infundibular epidermis; individual necrotic keratocytes; a lichenoid

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