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Dermatology Practical & Conceptual

Strategies for early recognition of cutaneous melanoma-present and future

…which correspond histologically to pagetoid spread of atypical melanocytes. (B) Obtained at the level of the dermo-epidermal junction showing the presence of large, nucleated cells (red arrows) corresponding to atypical melanocytes which are arranged…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…undulate between rete ridges and dermal papillae 5. Nests of melanocytes predominate over melanocytes disposed as solitary units 5. Abnormal melanocytes arrayed mainly as solitary units in at least some high-power fields 6. Nests of melanocytes r…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…infundibular and adnexal when eccrine ductal. Proliferation of melanocytes may be categorized according to an increase in the absolute number of normal-appearing melanocytes per unit area of dermoepidermal junction or basal layer of epidermis, either…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…, and the dark spots are believed to be typified by junctional melanocytes arranged in nests. In the presented case a punch biopsy of the nevus did not show a proliferation of melanocytes, but the biopsy was relatively small and sampling error cannot…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Invasion by Neoplastic Cells?

…standard practice in general pathology to describe neoplastic melanocytes of a primary melanoma, lodged not just in the epidermis but also in the dermis (or the subcutaneous fat), as invasive, but neoplastic melanocytes of a Spitz nevus positioned i…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Desmoplastic Spitz’s nevus

Pigmented macules and patches mostly in the middle third of the face, vertically and horizontally, distributed symmetrically and occurring mainly in postpubescent women as a consequence of the combined effects of estrogen and ultraviolet light on me…

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