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Differential Diagnosis in Dermatopathology

Interstitial granuloma annulare vs. Interstitial mycosis fungoides

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Differential Diagnosis in Dermatopathology

Discussions

…is a hint of crowding of bundles of collagen, the diagnosis is morphea. At times the interstitial infiltrates of the two very different diseases, mycosis fungoides and morphea, are very difficult to identify for what they are with precision. When his…

Histologic Diagnosis of Inflammatory Skin Diseases

Degos’ disease (malignant atrophic papulosis)

…r pattern. Atrophoderma of Pasini and Pierini, an end stage of morphea, tends to be hyperpigmented. Lichen sclerosus et atrophicans, a superficial manifestation of morphea, may present itself as small white macules, but those tend to be joined by a v…

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis chronica atrophicans

…cal of atrophy, except for “burned out” patches of morphea known as the “idiopathic atrophoderma Pasini and Pierini.” Lichen sclerosus et atrophicus, a superficial expression of morphea, consists of lesions that usually are sm…

Differential Diagnosis in Dermatopathology

Keloid vs. Hypertrophic scar

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Lipodystrophy

Lipodystrophy Synonyms Lipoatrophy Wucher atrophy Presentation stereotypical Age and sex Females, first decade of life Distribution of lesions Upper half of body in the “partial” expression of the process and widespread in the “t…

Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

By utilizing an algorithmic method based mostly on analysis of patterns formed by inflammatory cells, of alterations in epidermal and adnexal epithelium, and of the character of the inflammatory cells themselves, order can be brought to a subject ab…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophoderma?

“Atrophoderma, or atrophia cutis. Atrophy of the skin may be quantitative or qualitative; idiopathic or symptomatic; diffused or circumscribed. Crocker gives this useful table: Pigmentosum Juvenilis Albidum Diffusum Senilis…

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