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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…nt occurrence in this syndrome are cutaneous and subcutaneous nodules showing the typical connective tissue alteration. These are of significant value for diagnosis by biopsy.” Today, as in 1951, it is difficult for a reader with a critical tur…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Chondrodermatitis Nodularis Helicis?

…ear, and protrusions and depressions, as well as formation of nodules. It is very well possible, therefore, that cartilage thus changed has been damaged by some influence (of traumatic, chemical, or thermal nature). . . . Until the cause has been elu…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudomalignancies?

…is a special lesion, a pseudocancer, occurring as an isolated nodule, usually on the face, and mimicking squamous cell carcinoma.” Wolff K, Johnson RA, Suurmond D. Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology. 5th ed. N…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…red were referred to in times past as “pseudorheumatoid nodule.” In fact, they are those of granuloma annulare as evidenced by the abundant mucin in the center of some palisades of histiocytes. In short, there is rheumatoid nodule, but no…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…cum body-like inclusions = Farmer”s pox (Milker”s nodule/orf) + A few neutrophils sprinkled in the epidermis and a sparse perivascular infiltrate of lymphocytes mostly = Irritant contact dermatitis + Individual necrotic keratocytes an…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…l diagnosis clinical Erythema nodosum consists of tender red nodules and plaques that develop suddenly on the anterior surface of the legs and disappear in weeks without residua, save for hyperpigmentation. Hypodermitis sclerodermiformis tends to in…

Histologic Diagnosis of Inflammatory Skin Diseases

Chondrodermatitis nodularis helicis

…calized to the helix or anthelix Individual lesions Papule or nodule often crusted or keratotic, but sometimes smooth; an early papule usually is pink and smooth Differential diagnosis clinical Solar keratosis has a red base and/or adherent scale th…

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