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Study By Disease

Study By Disease

…uption, papulosquamous (lamotrigin) (Quiz #592) Drug eruption, peri-infundibulitic (Quiz #203) Drug eruption, perivascular and interstitial (Quiz #215) Drug eruption, perivascular and interstitial (presumably) (Quiz #213) Drug eruption, pustular (Qui…

Differential Diagnosis in Dermatopathology

Discussions

…ditions turns on the fact that acne vulgaris essentially is an infundibulitis, and not a peri-infundibulitis, whereas rosacea is both an infundibulitis and a peri-infundibulitis. Granulomatous inflammation is basic to papules of rosacea, where it ten…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ion alopecia is an inflammatory disease; it exhibits lichenoid peri-infundibulitis and perifolliculitis “early” in its course; trichotillomania, by contrast, is not an inflammatory disease. 10.108.2A: Section of a biopsy specimen fr…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…tular In infundibular epidermis: + Bacteria = Bacterial infundibulitis + Hyphae = Majocchi”s granuloma + No infectious agents = Any noninfectious suppurative infundibulitis, e.g., acne vulgaris, rosacea Just beneath surface epider…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…a patchy lichenoid infiltrate of lymphocytes. 11.14.35A: Peri-infundibulosis and perifolliculosis + 11.14.35B: Lymphocytes around venules and in considerable number in infundibula that contain plentiful mucin + 11.14.35C + 11.1…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…often, findings of residual solar lentigo are differentiating. Peri-infundibular and perifollicular accentuation of classic discoid lupus erythematosus and of traction alopecia: Both differ from lichen planopilaris, the former by changes at the dermo…

Differential Diagnosis in Dermatopathology

Perforating folliculitis vs. Elastosis perforans serpiginosa

An inflammatory process that often begins as a suppurative folliculitis manifested clinically as pustules. It rapidly extends to become ulcers marked at their periphery by boggy tissue. The skin disease is associated commonly with inflammatory bowel…

Histologic Diagnosis of Inflammatory Skin Diseases

Acne vulgaris

…bula and in the dermis. Findings histopathologic Early Sparse perivascular and peri-infundibular infiltrates of neutrophils and lymphocytes Plugs of corneocytes in widened infundibula (comedones) often Neutrophils in infundibula sometimes Fully dev…

Histologic Diagnosis of Inflammatory Skin Diseases

Keratosis pilaris/Lichen spinulosus

…neutrophils first are summoned to the site (slight suppurative peri-infundibulitis), followed by lymphocytes and then histiocytes (granulomatous peri-infundibulitis). Correlation clinicopathologic Acuminate infundibular keratoses are made up of corn…

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