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Histologic Diagnosis of Inflammatory Skin Diseases

Melanocytes

Melanocytes synthesize melanin. From precursors in the neural crest, melanocytes migrate normally to the epidermis, the bulb of hair follicles, epithelia of various mucous membranes, leptomeninges, inner ear, and a few other tissues (Fig. 1.61). Pri…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eczema?

“Eczema is that which looks like eczema.” Hebra F. Kaposi M. Lehrbuch der Hautkrankheiten. Bd, 2. Aufl. Erlangen: Enke, 1874:403-93. “In Anglo-American usage, the term dermatitis is being used increasingly for all these conditi…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

Subcutaneous T-cell lymphoma Synonyms Subcutaneous panniculitis-like lymphoma Presentation stereotypical Age and sex Mostly women in the third and fourth decades of life Distribution of lesions Extremities, trunk, face, neck, and breasts Arrangement…

Histologic Diagnosis of Inflammatory Skin Diseases

Gout

Gout Presentation stereotypical Age and sex Predominantly men Distribution of lesions Localized to ears and small joints, such as those of big toes Arrangement of lesions Discrete Individual lesions Papules, nodules, and even tumors Course Protracte…

Differential Diagnosis in Dermatopathology

Discussions

Distinction histopathologic between lichen planus-like keratosis and most solar keratosis is not difficult in some instances. When, however, a solar keratosis is accompanied by lichenoid infiltrates of lymphocytes, it may have many attributes in com…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.20.1A: Nodular dermatitis, granulomatous + 10.20.1B: Numerous extravasated erythrocytes, siderophages, and fibrocytes = Dermatofibroma An important finding for diagnosis of a dermatofibroma such as this one is seen at the periph…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

“-oid (-oid) [eides, like]. A suffix signifying likeness or resemblance.” Bould G. The Practitioner’s Medical Dictionary. 3rd ed. Philadelphia, PA: P. Blakiston’s Son & Co., 1916:622. “-ode, -odes, -oid, -oides […

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

See Fig. 5.174 A&B. Figure 5.174 A&B. Nodular dermatitis and diffuse dermatitis. Nodular dermatitis is distinguished from perivascular dermatitis (see Fig. 5.16 A&B) by the density of the infiltrate of inflammatory cells. In the periv…

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