Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

See Fig. 5.350 A&B. Figure 5.350 Fibrosing dermatitis. A. Early. B. Late (sclerosis). Fibrosing dermatitis (as well as fibrosing peri-infundibulitis/perifolliculitis and fibrosing panniculitis) results, in every instance, from injury to nonep…

Histologic Diagnosis of Inflammatory Skin Diseases

Cat-scratch disease

Cat-scratch disease Presentation stereotypical Age and sex Any age and either sex, but children and young adults preponderantly Distribution of lesions Localized at the site of a scratch or a bite by a cat Individual lesions Papules, pustules, or cr…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

Arthropod assaults Synonyms Insect “bite” Bug bite Insect bite reaction Papular urticaria Lichen urticatus Strophulus Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions At times only a single lesion a…

Histologic Diagnosis of Inflammatory Skin Diseases

Infundibulitis secondary to medications systemic

Infundibulitis secondary to medications systemic Comment Findings histopathologic in infundibulitis secondary to medications administered systemically are no different from those in suppurative infundibulitis of any noninfectious cause, with the exc…

Differential Diagnosis in Dermatopathology

Discussions

Perforating folliculitis and elastosis perforans serpiginosa have several findings histopathologic in common: an epithelial channel through surface epidermis; neutrophils in the channel; a collection of neutrophils contiguous with the channel; foci…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

In 1963, the year that one of us (A.B.A.) began a residency in dermatology, Walter Lever’s textbook, Histopathology of the Skin, was in its third edition and was deemed, universally, to be “the bible” of dermatopathology. To a firs…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.84.1A: Vasculitis, large-vessel, mixed cell + 10.84.1B: Thrombus within the lumen of an artery situated in the subcutaneous fat and a mix of inflammatory cells in the wall of it = Polyarteritis nodosa ┬áThe infiltrate of inflamma…

Differential Diagnosis in Dermatopathology

Discussions

Erythematous papules of acne vulgaris and of rosacea have in common localization mostly to the face, suppurative infundibulitis, and a mixed infiltrate of inflammatory cells in the dermis, it containing lymphocytes and plasma cells, and sometimes hi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.27.1A: Pustular dermatitis, infundibular + 10.27.1B: Perivascular and interstitial infiltrate of many neutrophils and innumerable eosinophils in infundibula and sebaceous lobules = Eosinophilic pustular folliculitis Because eosi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Changing Mole?

“Any single nevus that is noted to change independently should be cause for alarm.” Rhodes AR. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al., eds., Dermatology…