Differential Diagnosis in Dermatopathology

Differential Diagnosis

Xanthogranuloma Necrobiotic xanthogranuloma 1. Surface domed 1. Surface flat 2. Infiltrate often well circumscribed 2. Infiltrate poorly circumscribed 3. Infiltrate often embraced partially by collarettes of epithelium 3. No collarettes of e…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudomalignancies?

…hey may be inflammatory diseases, such as dermatofibromas and xanthogranulomas with “monster cells.” Irrespective of the essential nature of the process pathologic, the term pseudomalignancy (pseudocarcinoma, pseudolymphoma, pseudosarcoma…

Differential Diagnosis in Dermatopathology

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Xanthogranuloma Necrobiotic xanthogranuloma

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Necrobiosis lipoidica Necrobiotic xanthogranuloma 1. Infiltrates of inflammatory cells equally dense throughout the dermis or “top-heavy” 1. Infiltrates of inflammatory cells “bottom-heavy” 2. Septal panniculitis with s…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Xanthogranuloma Reticulohistiocytic granuloma 1. Cytoplasm of histiocytes foamy usually; not usually finely granular 1. Cytoplasm of histiocytes finely granular usually; foamy sometimes 2. Cytoplasm of histiocytes usually abundant, pale, and d…

Differential Diagnosis in Dermatopathology

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Necrobiosis lipoidica Necrobiotic xanthogranuloma

Dermatology Practical & Conceptual

Yellow color upon dermatoscopy does not exclude melanoma!

…n tumors with sebaceous differentiation, but also in juvenile xanthogranuloma or granulomatous skin diseases [1]. It is more surprising that recent dermatoscopic observations report on yellow color in both melanocytic nevi and melanoma [2,3]. Herein…