Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

“With the high power the hyaline is seen in very varied forms, which all show the same fuchsin red reaction. The first forms a section by itself; it comprises hyaline balls of different size, which lie free between the epithelial cells, and w…

Differential Diagnosis in Dermatopathology

Trichoepithelioma vs. Infundibulocystic basal-cell carcinoma

A disease of infundibulosebaceous units, especially infundibula, that may manifest itself solely as noninflammatory lesions, i.e., comedones and intact cysts, or as inflammatory lesions, i.e., papules, nodules, and pustules. The process may resolve…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

In 1963, the year that one of us (A.B.A.) began a residency in dermatology, Walter Lever’s textbook, Histopathology of the Skin, was in its third edition and was deemed, universally, to be “the bible” of dermatopathology. To a firs…

Differential Diagnosis in Dermatopathology

Dilated pore vs. Pilar sheath acanthoma

A disease of infundibulosebaceous units, especially infundibula, that may manifest itself solely as noninflammatory lesions, i.e., comedones and intact cysts, or as inflammatory lesions, i.e., papules, nodules, and pustules. The process may resolve…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ilia present often 9. No comedones or milia 10. Infundibular cysts and sinus tracts may be accompaniments 10. No infundibular cysts or sinus tracts 11. Telangiectasias not remarkable 11. Telangiectasias often striking 12. Little or no solar ela…

Differential Diagnosis in Dermatopathology

Discussions

Erythematous papules of acne vulgaris and of rosacea have in common localization mostly to the face, suppurative infundibulitis, and a mixed infiltrate of inflammatory cells in the dermis, it containing lymphocytes and plasma cells, and sometimes hi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Primary and Secondary Lesions?

“Some of the appearances observed in cutaneous diseases are caused directly by the deposition of morbid products in the skin. These bear the name of Primary symptoms or eruptions, Efflorescentiae cutaneae primariae. But these eruptions often…

Histologic Diagnosis of Inflammatory Skin Diseases

Acquired epidermolysis bullosa

Acquired epidermolysis bullosa Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Predilection for skin above joints and at sites of trauma; oral lesions sometimes Individual lesions Vesicles, bullae, scars, and mili…

Differential Diagnosis in Dermatopathology

Discussions

In general, neoplasms metastatic to the skin present little difficulty in differential diagnosis from neoplasms primary in the skin. Carcinoma of the breast is an exception. If there are but a few neoplastic cells and numerous inflammatory cells sca…

Histologic Diagnosis of Inflammatory Skin Diseases

"Folliculitis" (Infundibulitis)

“Folliculitis” (Infundibulitis) Synonyms What is designated, universally, folliculitis is, in actuality, infundibulitis. In short, infundibulitis is NOT a synonym for folliculitis; the former, for purposes practical, is a suppurative pro…