Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

In 1963, the year that one of us (A.B.A.) began a residency in dermatology, Walter Lever’s textbook, Histopathology of the Skin, was in its third edition and was deemed, universally, to be “the bible” of dermatopathology. To a firs…

Histologic Diagnosis of Inflammatory Skin Diseases

"Folliculitis" (Infundibulitis)

“Folliculitis” (Infundibulitis) Synonyms What is designated, universally, folliculitis is, in actuality, infundibulitis. In short, infundibulitis is NOT a synonym for folliculitis; the former, for purposes practical, is a suppurative pro…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Primary and Secondary Lesions?

“Some of the appearances observed in cutaneous diseases are caused directly by the deposition of morbid products in the skin. These bear the name of Primary symptoms or eruptions, Efflorescentiae cutaneae primariae. But these eruptions often…

Differential Diagnosis in Dermatopathology

Dilated pore vs. Pilar sheath acanthoma

A papular and pustular inflammatory process that is centered in follicles and is distributed mostly in the middle third of the face in both vertical and horizontal directions. Among the varied manifestations of rosacea are innumerable telangiectases…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ilia present often 9. No comedones or milia 10. Infundibular cysts and sinus tracts may be accompaniments 10. No infundibular cysts or sinus tracts 11. Telangiectasias not remarkable 11. Telangiectasias often striking 12. Little or no solar ela…

Histologic Diagnosis of Inflammatory Skin Diseases

Acquired epidermolysis bullosa

Acquired epidermolysis bullosa Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Predilection for skin above joints and at sites of trauma; oral lesions sometimes Individual lesions Vesicles, bullae, scars, and mili…

Differential Diagnosis in Dermatopathology

Discussions

In general, neoplasms metastatic to the skin present little difficulty in differential diagnosis from neoplasms primary in the skin. Carcinoma of the breast is an exception. If there are but a few neoplastic cells and numerous inflammatory cells sca…

Differential Diagnosis in Dermatopathology

Trichoepithelioma vs. Infundibulocystic basal-cell carcinoma

A papular and pustular inflammatory process that is centered in follicles and is distributed mostly in the middle third of the face in both vertical and horizontal directions. Among the varied manifestations of rosacea are innumerable telangiectases…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Myxoma?

“myxoma (milk – s ? m?) [myxo - + G. -oma, tumor]. A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mes…