Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

“Pruritic urticarial papules and plaques of pregnancy (PUPPP) was recently defined as an intensely pruritic cutaneous eruption occurring in the third trimester. . . . The overall picture was nonspecific and ranged from one suggestive of eryt…

Histologic Diagnosis of Inflammatory Skin Diseases

Livedo vasculitis

Livedo vasculitis Synonyms Livedoid vasculopathy Atrophie blanche Atrophie alba PURPLE (painful purpuric ulcers with reticular pattern of the lower extremities) Livedo reticularis with summer ulcerations Livedo with ulceration Milian’s white…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

“Perforating dermatoses: . . . various cutaneous disorders are discussed in which the process of perforation and elimination of various tissue components plays a major role in the basic pathologic mechanism. These include perforating granulom…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Granuloma annulare Necrobiosis lipoidica 1. Epidermis not thinned 1. Epidermis usually thinned with effacement of rete ridges 2. Upper part of the reticular dermis usually more involved than the lower part; subcutaneous fat spared in papules 2…

Differential Diagnosis in Dermatopathology

Images

Necrobiosis lipoidica Necrobiotic xanthogranuloma…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Necrobiosis lipoidica Necrobiotic xanthogranuloma 1. Infiltrates of inflammatory cells equally dense throughout the dermis or “top-heavy” 1. Infiltrates of inflammatory cells “bottom-heavy” 2. Septal panniculitis with s…

Differential Diagnosis in Dermatopathology

Images

Granuloma annulare Necrobiosis lipoidica…

Histologic Diagnosis of Inflammatory Skin Diseases

Hypodermitis sclerodermiformis

Hypodermitis sclerodermiformis Synonyms Hypodermatitis sclerodermiformis Hypodermitis sclerositans Liposclerosis Lipodermatosclerosis Stasis dermatosclerosis Sclerotic panniculitis Sclerosing panniculitis Presentation stereotypical Age and sex Adult…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…