Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

“The term necrotizing angiitis has proved to be a convenient generic term for the entire group of vascular lesions, both arterial and venous, in which the fully developed stage is characterized by fibrinoid necrosis and inflammation involving…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Granuloma annulare Necrobiosis lipoidica 1. Epidermis not thinned 1. Epidermis usually thinned with effacement of rete ridges 2. Upper part of the reticular dermis usually more involved than the lower part; subcutaneous fat spared in papules 2…

Differential Diagnosis in Dermatopathology

Images

Necrobiosis lipoidica Necrobiotic xanthogranuloma…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Necrobiosis lipoidica Necrobiotic xanthogranuloma 1. Infiltrates of inflammatory cells equally dense throughout the dermis or “top-heavy” 1. Infiltrates of inflammatory cells “bottom-heavy” 2. Septal panniculitis with s…

Differential Diagnosis in Dermatopathology

Images

Granuloma annulare Necrobiosis lipoidica…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…

Histologic Diagnosis of Inflammatory Skin Diseases

Hypodermitis sclerodermiformis

Hypodermitis sclerodermiformis Synonyms Hypodermatitis sclerodermiformis Hypodermitis sclerositans Liposclerosis Lipodermatosclerosis Stasis dermatosclerosis Sclerotic panniculitis Sclerosing panniculitis Presentation stereotypical Age and sex Adult…

Histologic Diagnosis of Inflammatory Skin Diseases

Leishmaniasis

Leishmaniasis Synonyms Leishmaniosis Presentation stereotypical Age and sex Young adults of both sexes Distribution of lesions Localized in Oriental sore, widespread in the mucocutaneous and post-kala-azar types, and disseminated in the anergic cuta…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

Leukocytoclastic vasculitis Synonyms Leukocytoclastic angiitis Allergic vasculitis Hypersensitivity angiitis Hypersensitivity vasculitis Anaphylactoid purpura Immune complex vasculitis Purpura rheumatica Presentation stereotypical Age and sex Any ag…