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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Overlap Syndromes?

…us erythematosus and lichen planus, seborrheic dermatitis and psoriasis, and morphea and lichen sclerosus et atrophicus. On the basis of our study of lesions reputed to be representative of overlap syndromes, we have come to a different conclusion, n…

Differential Diagnosis in Dermatopathology

Discussions

Psoriasis on volar skin and dyshidrotic dermatitis—the latter a disease that virtually always is restricted to volar skin or skin immediately adjacent to it—often share findings histopathologic: scale-crusts, psoriasiform acanthosis, foc…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…ample, whether it is a drug eruption, nummular dermatitis, or psoriasis on one hand or mycosis fungoides on the other. For purposes of diagnosis specific, however, that limitation is overcome by spotting telltale signs, e.g., wiry bundles of collagen…

Differential Diagnosis in Dermatopathology

Discussions

Guttate psoriasis and seborrheic dermatitis have several findings histopathologic in common, among them mounds of parakeratosis that contain neutrophils, a granular zone thinned slightly in foci, slight acanthosis, dilated blood vessels in the upper…

Differential Diagnosis in Dermatopathology

Discussions

Lesions of psoriasis and of pityriasis rubra pilaris developed fully have numerous findings histopathologic in common—so many, in fact, that some authors continue to believe, incorrectly, that the two diseases are indistinguishable from one another…

Differential Diagnosis in Dermatopathology

Discussions

Psoriasis and nummular dermatitis share several attributes histopathologic, namely, parakeratosis that often is accompanied by serum, psoriasiform acanthosis, spongiosis, edema of the papillary dermis, and an infiltrate of lymphocytes mostly around…

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rubra pilaris

…enile and adults types exist. Differential diagnosis clinical Psoriasis has a characteristic distribution, e.g., predilection for elbows and knees, lacks infundibulocentric arrangement, possesses silvery scales, and often involves nails. As a rule, n…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…he findings in the epidermis are very different from those of psoriasis at every stage of it, in particular, the combination of a checkerboard pattern of orthokeratosis and parakeratosis, of notable granular zone, and absence of neutrophils. Those at…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…ar person ever displays. Variations clinical Large-plaque parapsoriasis presents itself as patches, sometimes more than 10 cm in diameter, situated especially on thighs and buttocks, but also at times on the trunk. When it is associated with a yellow…

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