Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

Granuloma faciale Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized to the face Shape of lesions Round or oval usually Individual lesions Papules, plaques, nodules, or tumors marked on their surface often…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

“Eleven out of 17 presented with chilblain LE after the development of facial discoid LE and the delay varied from 1 to 14 years (mean 5.9 years). . . . Three patients had chilblains and bad circulation before the onset of LE. The sites of th…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

Rosacea Synonyms Gutta rosea Presentation stereotypical Age and sex Young and middle-aged adults, usually Caucasian women Distribution of lesions Center of the face in vertical and horizontal directions, i.e., nose, forehead, cheeks, and chin Indivi…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Tuberculoid leprosy Sarcoidosis 1. Oblong aggregations made up of epithelioid histiocytes 1. Roundish aggregations composed of epithelioid histiocytes 2. Granulomas predominantly in the lower part of the dermis, less often in the upper part al…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiotic xanthogranuloma

Necrobiotic xanthogranuloma Presentation stereotypical Age and sex Middle-aged and older persons of both sexes Distribution of lesions Periorbital region particularly, but trunk, extremities, and neck sometimes affected Individual lesions Papules, n…

Differential Diagnosis in Dermatopathology

Images

Tuberculoid leprosy Sarcoidosis

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema figuratum

Erythema figuratum Synonyms Erythema figuratum perstans Figurate erythema Annular erythema Presentation stereotypical Age and sex Adults of both sexes, but women especially Distribution of lesions Localized or widespread, trunk and proximal extremit…

What is Rosacea?

What is Rosacea?

Rosacea is a common inflammatory facial skin disorder classically marked by flushing, facial erythema, inflammatory papules and pustules, and telangiectasias. It typically presents in adults, with prevalence reported as 1 to greater than 20%, with a…