Dermatology Practical & Conceptual

From the Dermatologikum Hamburg: Quiz

…ease that first comes to mind when looking at this pattern is sarcoidosis. However, the clinical presentation with few localized small nodules or papules in a child would be very unusual. Interestingly, nodular aggregations of macrophages in this cas…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

…fundibula Course Protracted Differential diagnosis clinical Sarcoidosis presents itself usually as numerous scattered papules that, on the face, tend to aggregate around the eyes, nose, and mouth; lesions lack dilated ostia of infundibula. Polymo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…on lupus pernio, which simply is a cutaneous manifestation of sarcoidosis, consisting, as it does, of smooth, shiny violaceous plaques made up of collections of epithelioid histiocytes and situated on the ears, forehead, and nose. Although the word p…

Histologic Diagnosis of Inflammatory Skin Diseases


…as the center of the face, and is unaffiliated with pustules. Sarcoidosis of the face is papular entirely and favors the region of the nose, as well as that of the eyes and mouth, and is unaffiliated with telangiectases and rhinophyma. Findings hist…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

…Giant cell lichenoid dermatitis: a possible manifestation of sarcoidosis. J Cutan Pathol. 1994;21:47-51. 8. Gonzalez JG, Marcus MD, Santa Cruz DJ. Giant cell lichenoid dermatitis. J Am Acad Dermatol. 1986;15:87-92. 9. De Eusebio Murillo E, Yus E…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Tuberculoid leprosy Sarcoidosis 1. Oblong aggregations made up of epithelioid histiocytes 1. Roundish aggregations composed of epithelioid histiocytes 2. Granulomas predominantly in the lower part of the dermis, less often in the upper part al…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiotic xanthogranuloma

…redicts the prognosis in Scandinavian patients with pulmonary sarcoidosis. Am J Respir Crit Care Med 1997;156:1601-605. Chang SE, Lee WS, Lee MW et al. A case of necrobiotic xanthogranuloma without paraproteinemia presenting as a solitary tumor on th…

Differential Diagnosis in Dermatopathology


Tuberculoid leprosy Sarcoidosis

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

…damaged badly by sunlight. Differential diagnosis clinical Sarcoidosis may be annular, especially in Africans and African-Americans, but the lesions usually show a predilection for the face, particularly in the vicinity of the eyes, nose, and mout…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema figuratum

…er, any more than annular lesions of lichen planus, syphilis, sarcoidosis, granuloma annulare, and erythema multiforme are related to one another by virtue of the ring shape of them. Moreover, the so-called superficial type of figurate erythema (the…