Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.59.1A: Perivascular dermatitis, interface, focally lichenoid + 10.59.1B: Beneath a thinned epidermis, obscuration partially of the dermoepidermal junction by an infiltrate of lymphocytes and histiocytes = Lichen nitidus, early…

Histologic Diagnosis of Inflammatory Skin Diseases

Behçet’s Disease

Behçet”s disease Synonyms Aphthosis Behçet Aphthosis Presentation stereotypical Age and sex Onset usually in the third decade of life with male predominance Distribution of lesions Face for acneiform lesions, lower extremities for panniculit…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

Erythema nodosum leprosum Features clinical Red nodules or plaques that may develop anywhere but especially the thighs and legs Findings histopathologic Early Suppurative lobular panniculitis, focal at first and then diffuse Patchy zones of extensi…

Differential Diagnosis in Dermatopathology

Discussions

Erythema nodosum and nodular vasculitis are stereotypes of septal and lobular panniculitis, respectively. When developed fully, erythema nodosum is a granulomatous and fibrosing septal panniculitis and nodular vasculitis is a necrotizing, suppurativ…

Differential Diagnosis in Dermatopathology

Discussions

Nodular vasculitis and subcutaneous polyarteritis nodosa are inflammatory diseases that affect medium-sized and large arteries situated in fibrous septa of the subcutaneous fat. Both conditions involve the subcutaneous fat mostly, although signs of…

Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

Crohn’s disease Synonyms Inflammatory bowel disease Regional ileitis Regional enteritis Chronic cicatrizing enteritis Presentation stereotypical Age and sex Young adults; slight predominance of women Distribution of lesions The poles of the ga…

Differential Diagnosis in Dermatopathology

Nodular vasculitis vs. Subcutaneous polyarteritis nodosa

Infection of skin and subcutaneous tissue by atypical mycobacteria, that is, mycobacteria other than those responsible for tuberculosis and leprosy, expressed clinically as keratotic and crusted papules, plaques, nodules, and tumors that may be punc…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum

Erythema nodosum Synonyms Erythema contusiforme Erythema contusiformis Dermatitis contusiformis Erythema nouesux Presentation stereotypical Age and sex Young adults, especially women Distribution of lesions Bilateral and symmetrical over the pretibi…

Differential Diagnosis in Dermatopathology

Erythema nodosum vs. Nodular vasculitis

Infection of skin and subcutaneous tissue by atypical mycobacteria, that is, mycobacteria other than those responsible for tuberculosis and leprosy, expressed clinically as keratotic and crusted papules, plaques, nodules, and tumors that may be punc…