Differential Diagnosis in Dermatopathology

Discussions

…ranes and nail units. Darier’s disease does not exhibit vesicles clinically or histopathologically. Prior to the use of retinoids, Darier’s disease was largely refractory to treatment. The term “keratosis follicularis” as a sy…

Differential Diagnosis in Dermatopathology

Study By Disease

…Telangiectasia macularis eruptiva perstans (Quiz #430) Tense vesicle in response to the “bite” directly of an insect (Quiz #218) Tinea versicolor (Quiz #198) Traumatic (factitious) ulcer (Quiz #889) Traumatic purpura and ulceration (Quiz…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…No edema noticeable in the papillary dermis 2. Subepidermal vesicle sometimes secondary to marked edema of the papillary dermis 2. No subepidermal vesiculation 3. Many erythrocytes extravasated in the upper part of the dermis commonly 3. Few, if…

Differential Diagnosis in Dermatopathology

Insect "bite" vs. Lymphomatoid papulosis

A blistering inflammatory disease in which acantholysis occurs in the upper part of the spinous zone or granular zone of the epidermis, the result of the process being flaccid blisters that give way to erosions and crusts accompanied by erythema. Wh…

Differential Diagnosis in Dermatopathology

Discussions

…a of the papillary dermis, and a central tense intraepidermal vesicle. The changes in the dermis just described are encountered in an urticarial response to assaults by arthropods. There are few, if any, alterations in the epidermis of those lesions….

Differential Diagnosis in Dermatopathology

Discussions

…ntionally, is a burrow bounded often by a tiny intraepidermal vesicle at its far end, the site to which the female mite has advanced in the cornified layer. The infiltrate in a typical papule of scabies is like that of an insect “bite,” i…

Differential Diagnosis in Dermatopathology

Discussions

…hat share many findings histopathologic, e.g., intraepidermal vesicles surrounded by ballooned keratocytes, reticular alteration, and signs of necrosis of what originally were steel-gray nuclei. Viral inclusions are harbored in keratocytes of both di…

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…ions Intensely pruritic urticarial papules and plaques, papulovesicles, vesicles, crusted papules, scaly papules, and pigmented macules Course Papules occur in crops, extraordinarily pruritic at the outset; eruption waxes and wanes, intervals of free…

Differential Diagnosis in Dermatopathology

Nodular scabies vs. Lymphomatoid papulosis

A blistering inflammatory disease in which acantholysis occurs in the upper part of the spinous zone or granular zone of the epidermis, the result of the process being flaccid blisters that give way to erosions and crusts accompanied by erythema. Wh…