Differential Diagnosis in Dermatopathology

Discussions

In an urticarial reaction to an assault by an arthropod and in lesions of true urtica, the infiltrate of inflammatory cells is mixed, contains at least lymphocytes and usually eosinophils, and is accompanied by extravasated erythrocytes and edema of…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…extensive, eventuates in subepidermal clefts and subepidermal vesicles Marked spongiosis and ballooning; if ballooning extensive sufficiently, reticular alteration and intraepidermal vesicles ensue Intraepidermal and subepidermal vesiculation may oc…

Differential Diagnosis in Dermatopathology

Insect "bite" vs. Lymphomatoid papulosis

A blistering inflammatory disease in which acantholysis occurs in the upper part of the spinous zone or granular zone of the epidermis, the result of the process being flaccid blisters that give way to erosions and crusts accompanied by erythema. Wh…

Differential Diagnosis in Dermatopathology

Discussions

Nodular scabies and lymphomatoid papulosis have many attributes histopathologic in common. Both consist of infiltrates whose pattern is superficial and deep, perivascular, and interstitial, and whose population of cells may be mixed, i.e., small lym…

Differential Diagnosis in Dermatopathology

Discussions

…ed on a petal of a rose, i.e., small, tense, often umbilicated vesicles grouped on a red base. An individual vesicle of herpes simplex is indistinguishable from one of zoster or varicella, but the three diseases can be differentiated clinically from…

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

Prurigo pigmentosa Synonym Nagashima’s disease Presentation stereotypical Age and sex Young women in the second and third decade of life are affected mostly; no family history is obtainable Distribution of lesions Symmetric on the trunk with p…

Differential Diagnosis in Dermatopathology

Nodular scabies vs. Lymphomatoid papulosis

A blistering inflammatory disease in which acantholysis occurs in the upper part of the spinous zone or granular zone of the epidermis, the result of the process being flaccid blisters that give way to erosions and crusts accompanied by erythema. Wh…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

A blistering inflammatory disease in which acantholysis occurs in the upper part of the spinous zone or granular zone of the epidermis, the result of the process being flaccid blisters that give way to erosions and crusts accompanied by erythema. Wh…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

Erythema multiforme Synonyms Herpes iris Ectodermis erosive pluriorificialis Erytheme polymorphe Erythema multiforme exsudativum minor (Erythema multiforme minor, Erythema multiforme simplex, Erythema papulosum [Papular erythema multiforme]) Present…