Differential Diagnosis in Dermatopathology

Discussions

A proliferation of keratocytes that simulates squamous-cell carcinoma and authentic squamous-cell carcinoma itself have findings histopathologic in common, including epithelial cells that cornify, nuclei of epithelial cells that are not entirely typ…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.70.1A: Panniculitis, septal mostly + 10.70.1B: Fibrosing granulation tissue, abundant mucin, and scattered lymphocytes = Nodular fasciitis ┬áThe changes pictured are a response to external trauma akin to those in an early stage o…

Differential Diagnosis in Dermatopathology

Images

Dermatofibroma with “monster” cells Malignant fibrous histiocytoma…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiotic xanthogranuloma

Necrobiotic xanthogranuloma Presentation stereotypical Age and sex Middle-aged and older persons of both sexes Distribution of lesions Periorbital region particularly, but trunk, extremities, and neck sometimes affected Individual lesions Papules, n…

Dermatology Practical & Conceptual

Melanoma and satellite blue papule

Abstract The colors that are seen in dermoscopy depend on the anatomic level of the skin at which the chromophores are seen. Blue color can be found in a variety of melanocytic and nonmelanocytic lesions. An 89-year-old man presented with a 3-year h…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Dermatofibroma with “monster” cells Malignant fibrous histiocytoma 1. Symmetric 1. Asymmetric 2. Vertical orientation sometimes 2. No vertical orientation 3. Vasculature prominent 3. Vasculature not prominent 4. Few, if any, mi…

Differential Diagnosis in Dermatopathology

Images

Xanthomatous dermatofibroma Xanthomatous malignant fibrous histiocytoma…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Dermatofibroma Dermatofibrosarcoma protuberans 1. Rather well-circumscribed, small lesion, often contained wholly in a 4.0 mm biopsy specimen 1. Poorly circumscribed broad lesion, practically never contained wholly in a 4.0 mm biopsy specimen…