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Differential Diagnosis in Dermatopathology

"Pseudolymphoma," B-cell type vs. Malignant lymphoma, B-cell type

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…is represent pathologic, or at least, not “normal” cells, which is difficult to accept. If, on the other hand, the LC is considered a specific histiocytic cell which normally occurs within the connective tissues and within stratified squa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cutaneous T-cell Lymphoma?

…(CTCL), also known as mycosis fungoides, consists of malignant cells that resemble mature T cells. Vargo N. Cutaneous malignancies: KA, CTCL, and KS. Dermatol Nurs. 2006;18(3):270,277. New designations for diseases do not always represent an advanc…

Histologic Diagnosis of Inflammatory Skin Diseases

Adult T-cell leukemia/Lymphoma

Adult T-cell leukemia/Lymphoma Presentation stereotypical Age and sex No predilection for sex. Middle-aged individuals from southern Japan and Caribbean Islands. Distribution of lesions Widespread Arrangement Scattered discrete lesions Individual le…

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…e sampled for histopathologic examination and revealed a dense cellular infiltrate made up of mononuclear cells with conspicuous eosinophilic cytoplasm and large cleaved vesicular nucleus, some of them with shapes resembling the format of a kidney an…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…mis and subcutaneous fat. Histiocytosis X (Langerhans” cell histiocytosis) consists of a dense infiltrate of abnormal Langerhans” cells characterized by large, pale, reniform nuclei and abundant amphophilic cytoplasm, many eosinophils,…

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