Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…vulgares in an immunosuppressed infant are not accompanied by vesicles or by whorls of pigmentation Lichen striatus is not associated with vesicles Pigmented stage: Certain pigmented nevi unassociated with an increased number of melanocytes in the…

Histologic Diagnosis of Inflammatory Skin Diseases

Irritant contact dermatitis/Phototoxic dermatitis

Irritant contact dermatitis/Phototoxic dermatitis Synonyms Acute nonallergic contact dermatitis Primary irritant dermatitis External toxidermas Irritant dermatitis Presentation stereotypical Age and sex Any age, both sexes Distribution of lesions Ex…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…. Necrosis of the epidermis may be diffuse 2. Intraepidermal vesicle most pronounced at the actual site of the “bite” 2. Intraepidermal vesicles, when present, distributed randomly 3. Discrete collection of eosinophils in the epidermi…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…5. Several foci of spongiosis in some sections 6. Spongiotic vesicle or vesicles sometimes 6. No vesiculation 7. Infiltrate of inflammatory cells moderately dense 7. Infiltrate of inflammatory cells relatively sparse 8. Infiltrate in the inters…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

Psoriasis Presentation stereotypical Age and sex Persons of any age and of both sexes Distribution of lesions Localized, e.g., single papule or plaque, or universal, i.e., erythroderma; between these extremes, a preference for elbows and knees, scal…