Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

…nnular Individual lesions Macules, patches, papules, plaques, vesicles, bullae, erosions, and ulcerations Course Lesions heal within weeks without residua, save for hyperpigmentation Variations clinical Confined to either skin or mucous membranes, e…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…ent of lesions Linear, streaks, and whorls Individual lesions Vesicles, bullae, verrucous keratotic papules, pigmented macules and patches, and atrophic macules and patches Course At times concluding at term or ending sometime during infancy, the evi…

Histologic Diagnosis of Inflammatory Skin Diseases

Irritant contact dermatitis/Phototoxic dermatitis

…of redness and vesiculation Individual lesions Papules, papulovesicles, vesicles, and bullae Course Limited; usually beginning to wane shortly after the offending agent has been removed Variations clinical Irritant contact dermatitis Acute irritant…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…Necrosis of the epidermis may be diffuse 2. Intraepidermal vesicle most pronounced at the actual site of the “bite” 2. Intraepidermal vesicles, when present, distributed randomly 3. Discrete collection of eosinophils in the epidermis…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…. Several foci of spongiosis in some sections 6. Spongiotic vesicle or vesicles sometimes 6. No vesiculation 7. Infiltrate of inflammatory cells moderately dense 7. Infiltrate of inflammatory cells relatively sparse 8. Infiltrate in the interst…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

…ressed keratocytes at the periphery of a tense intraepidermal vesicle on a palm or sole is a clue to pustular psoriasis or dermatophytosis. Thin, elongated epidermal rete ridges of nearly equal length above a superficial infiltrate of inflammatory ce…