Search Results for: vesicle

Differential Diagnosis in Dermatopathology

Discussions

…lesions of herpes simplex have been likened to dew drops poised on a petal of a rose, i.e., small, tense, often umbilicated vesicles grouped on a red base. An individual vesicle of herpes simplex is indistinguishable from one of zoster or…

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…rphologic are singular. Clinically, prurigo pigmentosa presents itself as extraordinarily pruritic urticarial papules, papulovesicles, and vesicles arranged in reticulate pattern and distributed symmetrically on the chest, neck, and back, where it…

Differential Diagnosis in Dermatopathology

Nodular scabies vs. Lymphomatoid papulosis

…tory disease of older people; signs include widespread erythematous macules and patches, urticarial papules and plaques, and vesicles and bullae, the blisters often arising on urticarial plaques. Sometimes lesions are localized, e.g., to the legs….

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

…tory disease of older people; signs include widespread erythematous macules and patches, urticarial papules and plaques, and vesicles and bullae, the blisters often arising on urticarial plaques. Sometimes lesions are localized, e.g., to the legs….

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

…nd individual necrotic keratocytes. Sometimes, the infiltrate of lymphocytes even may qualify as being lichenoid. When tense vesicles and bullae are biopsied, they may exhibit well-defined ballooning of spinous keratocytes in association with…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…rked by spongiosis that is accompanied by eosinophils, but the number of eosinophils is relatively few compared with that in vesicles of incontinentia pigmenti, and frank spongiotic vesicles come into being rarely. Bullous pemphigoid and herpes…

Histologic Diagnosis of Inflammatory Skin Diseases

Irritant contact dermatitis/Phototoxic dermatitis

…ic keratocytes in the epidermis Fully developed Same changes as in an early lesion plus: Prominent ballooning Intraepidermal vesicles associated with reticular alteration Extensive epidermal necrosis Late Same findings as in a fully developed lesion…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…he epidermis only at the actual site of the “bite” 1. Necrosis of the epidermis may be diffuse 2. Intraepidermal vesicle most pronounced at the actual site of the “bite” 2. Intraepidermal vesicles, when present, distributed…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…f spongiosis often at the site of the “bite” itself 5. Several foci of spongiosis in some sections 6. Spongiotic vesicle or vesicles sometimes 6. No vesiculation 7. Infiltrate of inflammatory cells moderately dense 7. Infiltrate of…