Search Results for: vesicle

Differential Diagnosis in Dermatopathology

Nodular scabies vs. Lymphomatoid papulosis

Circular orange-red-blue macule(s) or patch(es) that often becomes a papule(s) or plaque(s) and vesiculates, healing with hyperpigmentation, and that occurs repeatedly at the very same cutaneous and/or mucous membrane site(s), especially the…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

…ermatitides, i.e., allergic contact dermatitis, nummular dermatitis, dyshidrotic dermatitis, and “id” reactions. Vesicles may be seen in sections of tissue, and, not surprisingly, they even may be discernible clinically. The clue most…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…he epidermis only at the actual site of the “bite” 1. Necrosis of the epidermis may be diffuse 2. Intraepidermal vesicle most pronounced at the actual site of the “bite” 2. Intraepidermal vesicles, when present, distributed…

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…rphologic are singular. Clinically, prurigo pigmentosa presents itself as extraordinarily pruritic urticarial papules, papulovesicles, and vesicles arranged in reticulate pattern and distributed symmetrically on the chest, neck, and back, where it…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…f spongiosis often at the site of the “bite” itself 5. Several foci of spongiosis in some sections 6. Spongiotic vesicle or vesicles sometimes 6. No vesiculation 7. Infiltrate of inflammatory cells moderately dense 7. Infiltrate of…

Histologic Diagnosis of Inflammatory Skin Diseases

Irritant contact dermatitis/Phototoxic dermatitis

…ic keratocytes in the epidermis Fully developed Same changes as in an early lesion plus: Prominent ballooning Intraepidermal vesicles associated with reticular alteration Extensive epidermal necrosis Late Same findings as in a fully developed lesion…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…rked by spongiosis that is accompanied by eosinophils, but the number of eosinophils is relatively few compared with that in vesicles of incontinentia pigmenti, and frank spongiotic vesicles come into being rarely. Bullous pemphigoid and herpes…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

Circular orange-red-blue macule(s) or patch(es) that often becomes a papule(s) or plaque(s) and vesiculates, healing with hyperpigmentation, and that occurs repeatedly at the very same cutaneous and/or mucous membrane site(s), especially the…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

…nd individual necrotic keratocytes. Sometimes, the infiltrate of lymphocytes even may qualify as being lichenoid. When tense vesicles and bullae are biopsied, they may exhibit well-defined ballooning of spinous keratocytes in association with…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…mal vesicles Marked spongiosis and ballooning; if ballooning extensive sufficiently, reticular alteration and intraepidermal vesicles ensue Intraepidermal and subepidermal vesiculation may occur together Lymphocytes in association with neutrophils…