Differential Diagnosis in Dermatopathology

Discussions

Nodular vasculitis and subcutaneous polyarteritis nodosa are inflammatory diseases that affect medium-sized and large arteries situated in fibrous septa of the subcutaneous fat. Both conditions involve the subcutaneous fat mostly, although signs of…

Differential Diagnosis in Dermatopathology

Nodular vasculitis vs. Subcutaneous polyarteritis nodosa

An inflammatory disease caused by the spirochete Borrelia burgdorferi that manifests itself in the skin as erythematous lesions with figurate shapes, e.g., (round, ellipsoid, and arcuate) (erythema chronicum migrans), pseudolymphomatous nodules (lym…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus foliaceus

Pemphigus foliaceus Presentation stereotypical Age and sex Adults usually and of both sexes Distribution of lesions Localized to photodistribution in pemphigus erythematosus; widespread in pemphigus foliaceus Individual lesions Macules, patches, fla…

Histologic Diagnosis of Inflammatory Skin Diseases

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Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

Lupus erythematosus Synonyms Lupus erythematodes Presentation stereotypical Age and sex Young adult women especially, but sometimes neonates and older persons of both sexes. Distribution of lesions Often localized to sun-exposed sites such as the fa…

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis chronica atrophicans

Acrodermatitis chronica atrophicans Presentation stereotypical Age and sex Middle aged to elderly women especially Distribution of lesions Distal part of extremities, particularly of legs; nodules develop especially near knees and elbows Configurati…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…. Laboratory confirmation Genetic mapping for mutations in the Xp I I.21 or the Xq28 locus. Cause and mechanism This hereditary systemic disease is caused by an X-linked genetic defect in loci Xp I I.21 or Xq28, which is dominant in females and usual…

Differential Diagnosis in Dermatopathology

Discussions

Interstitial granulomatous dermatitis with arthritis, a distinctive disease that appears usually in patients with rheumatoid-like arthritis, has many attributes in common with the mostly interstitial type of granuloma annulare. Lesions of both condi…