Differential Diagnosis in Dermatopathology

Discussions

…licitable readily. Because the blisters develop consequent to ballooning mostly and/or to severe vacuolar alteration at the dermoepidermal junction and are huge, excessive loss of fluids and electrolytes is a serious complication, as it is in severe…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…titis) (see Figs. 5.18 and 5.19) and of the epidermis itself (ballooning [see Fig. 5.20], spongiotic [see Fig. 5.21], and psoriasiform dermatitis [see Fig. 5.22]), and each of those can be divided further, e.g., into perivascular and interstitial for…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…is, and in scale-crusts 6. Vesiculation common secondary to ballooning and/or spongiosis 6. Vesiculation uncommon, but secondary to ballooning mostly rather than spongiosis 7. Subepidermal vesiculation as common as intraepidermal vesiculation; so…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…is punctuated by numerous necrotic keratocytes and marked by ballooning and spongiosis. Bullous pemphigoid also is a single process in which eosinophils tend to predominate in the infiltrate, the interface between dermis and epidermis is not obscure…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ped The sequence of events in the epidermis was extraordinary ballooning of keratocytes that led to intraepidermal vesiculation accompanied by reticular alteration of the spinous zone and epidermal necrosis concurrent with it. Signs of infection by h…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ime 2. No psoriasiform acanthosis 3. Spongiosis, but little ballooning, in the epidermis 3. Ballooning, but little spongiosis, in the epidermis 4. Very few, if any, individual necrotic keratocytes in the epidermis 4. Numerous individual necrotic…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…unctuated by individual necrotic keratocytes, spongiosis, and ballooning. In lesions evolving, mounds of parakeratosis house neutrophils. Erythrocytes are extravasated in the papillary dermis (and sometimes in the epidermis) of lesions eruptive of Mu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…m those of graft-versus-host disease. The paucity of the infiltrate of lymphocytes and confinement of necrotic keratocytes to the lower part of the epidermis in the absence of either spongiosis or ballooning militate against erythema multiforme….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…to the diagnosis of this particular viral infection is the presence of ballooning in company with spongiosis, of incipient reticular alteration and necrosis of keratocytes, and of neutrophils in the upper part of the dermis and in the epidermis….