Differential Diagnosis in Dermatopathology

Differential Diagnosis

Dermatofibroma Dermatofibrosarcoma protuberans 1. Rather well-circumscribed, small lesion, often contained wholly in a 4.0 mm biopsy specimen 1. Poorly circumscribed broad lesion, practically never contained wholly in a 4.0 mm biopsy specimen…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Xanthomatous dermatofibroma Xanthomatous malignant fibrous histiocytoma 1. Lesion relatively well circumscribed 1. Lesion poorly circumscribed 2. No collarettes of epithelium 2. Collarettes of epithelium sometimes 3. Epidermis hyperpigmen…

Differential Diagnosis in Dermatopathology

Images

Xanthomatous dermatofibroma Xanthomatous malignant fibrous histiocytoma…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Dermatofibroma with “monster” cells Malignant fibrous histiocytoma 1. Symmetric 1. Asymmetric 2. Vertical orientation sometimes 2. No vertical orientation 3. Vasculature prominent 3. Vasculature not prominent 4. Few, if any, mi…

Differential Diagnosis in Dermatopathology

Pigmented Lesions

…r dermis too. Melanin increased in amount in the epidermis. Dermatofibroma (183, 520) Proliferation of fibrocytes and histiocytes (lipophages and siderophages early in the course) in a mass in the reticular dermis, those cells appearing to be spl…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Surface of dermatofibroma affiliated with follicular germs Surface of superficial basal-cell carcinoma 1. Acanthotic hyperpigmented epidermis; not ulcerated 1. Thin epidermis; sometimes eroded and/or ulcerated 2. Proliferations of germinative…

Differential Diagnosis in Dermatopathology

Images

Dermatofibroma Desmoplastic Spitz’s nevus…