Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.114.1A: Diffuse dermatitis, granulomatous + 10.114.1B: Foamy histiocytes, many of them multinucleate = Xanthogranuloma, fully developed  Lymphocytes, plasma cells, and eosinophils are scattered among the predominant histiocytes,…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…id 1. Subepidermal blister that contains neutrophils mostly; eosinophils in variable number, present, too, about 72 hours after onset 1. Subepidermal blister that contains eosinophils mostly; neutrophils in variable number may be present from near…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

Urticaria pigmentosa Synonyms Mastocytosis Presentation stereotypical Age and sex All ages and both sexes, but mostly nodules and blisters in infants and children, and mostly macules and papules in adults Distribution of lesions Localized or widespr…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

See Fig. 5.385 A-C. Figure 5.385 Patterns of panniculitis. A. Septal mostly. B. Lobular mostly. C. Septal and lobular “equally.” At scanning magnification, the normal subcutaneous fat is seen to be segregated by struts of fibrous tiss…

Histologic Diagnosis of Inflammatory Skin Diseases

Photoallergic dermatitis

Photoallergic dermatitis Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Sites exposed to sunlight especially, i.e., the face, the V region of the chest, forearms, and dorsa of hands; covered sites affected someti…

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…infiltrate of lymphocytes mostly, but also of neutrophils and eosinophils Nuclear “dust” of neutrophils accompanies intact neutrophils and the preponderant lymphocytes Mixed-cell infiltrate of lymphocytes, neutrophils, and eosinophils in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…and scale-crust = Grover’s disease The presence of many eosinophils in the papillary dermis indicates that this lesion must have been exceedingly pruritic. A nearly direct relationship exists between the number of eosinophils in Grover’s…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

“Inside the nose besides extensive necrosis, there is a cell-rich granulomatous tissue with granulomatous epithelioid cell foci which surround the vessels. . . . In both lungs: infarct-like necrosis in which one finds severe changes in the ve…