Histologic Diagnosis of Inflammatory Skin Diseases

Images

…thogranuloma, fully developed  Lymphocytes, plasma cells, and eosinophils are scattered among the predominant histiocytes, many of which are of Touton type, the stereotypical character of which is not apparent because of the angle at which they were…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma

…sometimes acanthotic Sprinkling of lymphocytes, plasma cells, eosinophils, and sometimes neutrophils throughout the infiltrate of histiocytes; lymphocytes and plasma cells around venules Late Fibroplasia amidst the dense diffuse infiltrate of foam…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…d 1. Subepidermal blister that contains neutrophils mostly; eosinophils in variable number, present, too, about 72 hours after onset 1. Subepidermal blister that contains eosinophils mostly; neutrophils in variable number may be present from near t…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…made up of a population of mononuclear cells joined often by eosinophils and neutrophils, but abnormal Langerhans” cells of that condition have kidney-shaped nuclei and abundant amphophilic cytoplasm devoid of granules. Those cells also may be…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…s many expressions, from linear scleroderma to fasciitis with eosinophils. In some instances, e.g., in exceptional, fully developed lesions of erythema nodosum, lobules and septa may be affected nearly equally (Fig. 5.388 A&B), a circumstance tha…

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…infiltrate of lymphocytes mostly, but also of neutrophils and eosinophils Nuclear “dust” of neutrophils accompanies intact neutrophils and the preponderant lymphocytes Mixed-cell infiltrate of lymphocytes, neutrophils, and eosinophils in…

Histologic Diagnosis of Inflammatory Skin Diseases

Photoallergic dermatitis

…eloped Superficial, and often deep, perivascular infiltrate; eosinophils, in variable number, in association with lymphocytes Marked edema of the papillary dermis Slight acanthosis Spongiotic vesicles Cornified layer either normal or covered by scal…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…and scale-crust = Grover’s disease The presence of many eosinophils in the papillary dermis indicates that this lesion must have been exceedingly pruritic. A nearly direct relationship exists between the number of eosinophils in Grover’s…