Search Results for: fibrin

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…a… Leukocytoclastic vasculitis: Much more abundant nuclear “dust” of neutrophils and the presence often of fibrin in the wall of venules. Dermatitis herpetiformis/linear IgA dermatosis: Neutrophils fill dermal papillae and are…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ls + 11.1.1B: Throughout the reticular dermis, an increased number of thick-walled venules lined by plump endothelial cells, fibrin in the wall of some venules, extravasated erythrocytes, and numerous siderophages + 11.1.1C + 11.1.1D =…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ultinucleate, in the wall of an artery and in a contiguous lobule = Temporal arteritis In polyarteritis nodosa, by contrast, fibrin often is present in the wall of the affected artery and the infiltrate of inflammatory cells in the adjacent lobules…

Differential Diagnosis in Dermatopathology

Discussions

Dermatitis herpetiformis and bullous pemphigoid share several findings, namely, subepidermal vesiculation, fibrin in subepidermal spaces, and a mix of inflammatory cells, among them lymphocytes and some neutrophils and eosinophils. The changes…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…phils in the upper part of the dermis = Crohn’s disease This fundamentally small-vessel vasculitis is characterized by fibrin in the wall of venules and thrombi in lumen of them. In addition, there are signs of suppuration, ulceration, and…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…nuclear “dust” of neutrophils invariable and abundant usually 1. No nuclear “dust” of neutrophils 2. Fibrin in and around the wall of venules 2. No fibrin in and around the wall of small vessels 3. No thrombi 3. Thrombi in…

Histologic Diagnosis of Inflammatory Skin Diseases

Persistent pigmented purpuric dermatitis

…e), spongiotic (Doucas and Kapetanakis), and lichenoid (Gougerot-Blum) dermatitis. They do not qualify as vasculitis because fibrin is not present in the wall of venules and thrombi are not found in the lumen of them. Bibliography Bibliography for…

Histologic Diagnosis of Inflammatory Skin Diseases

Disseminated intravascular coagulopathy

…f fibrinogen, platelets, prothrombin, and other factors of coagulation are notable, as well as is elevated split products of fibrin. Cause and mechanism The cause is activation of the coagulation process with consumption of fibrin, platelets, and…