Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Myxoma?

“myxoma (milk – s ? m?) [myxo – + G. -oma, tumor]. A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primiti…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…bules of amyloid 8. Clefts in nodules of colloid 9. Stellate fibrocytes and melanophages associated intimately with globules of amyloid 9. A few thin fibrocytes associated with colloid, but no macrophages 10. Angioplasia in conjunction with amylo…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

Lichen planus Synonyms Lichen ruber planus Lichen ruber Presentation stereotypical Age and sex More common in women, especially young and middle-aged adults Distribution of lesions Flexor surface of forearms and wrists, but no site is exempt. Occu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.14.1A: Perivascular dermatosis, psoriasiform lichenoid + 11.14.1B: Lymphocytes, sparse in both the dermis and epidermis, larger in the epidermis than in dermis, solitary in the basal layer in foci, and in association with scant…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

“This latter category, where the cells are destroyed during the course of the process, I proposed a few years ago to designate by a term which has been employed to express disease generally by K. H. Schultz, viz., necrobiosis. Necrobiosis is…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus?

“Strictly speaking, the term nevus denotes any congenital lesion of skin. Nevocellular nevus, however, refers to any congenital or acquired neoplasm of melanocytes.” Murphy GF, Mihm MC. The skin. In: Pathologic Basis of Disease. 6th ed…

Differential Diagnosis in Dermatopathology

Discussions

Lichen sclerosus et atrophicus, which is the superficial manifestation of morphea, and chronic radiation dermatitis are both fibrosing dermatitides that may resemble each other closely when viewed through the scanning objective of a conventional mic…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…throughout much of the dermis and sometimes the subcutis 5. Fibrocytes in the upper part of the dermis appear normal, i.e., having oval nuclei and scant cytoplasm 5. Fibrocytes in the upper part of the dermis are abnormal with long tails of cytopl…