Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ules of amyloid 8. Clefts in nodules of colloid 9. Stellate fibrocytes and melanophages associated intimately with globules of amyloid 9. A few thin fibrocytes associated with colloid, but no macrophages 10. Angioplasia in conjunction with amyloi…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…anged haphazardly, in conjunction with an increased number of fibrocytes, variable numbers of melanophages, and a sprinkling of lymphocytes. The cornified layer may have returned to its normal basket-weave configuration. A clue to diagnosis of atroph…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Myxoma?

…pithelium that produces mucin, whereas in pretibial myxedema, fibrocytes do it, presumably in concert with mast cells. Nonepithelial, or connective tissue, mucin is dominant in those benign and malignant cutaneous neoplasms said to be myxoid. In most…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…of the effects of longstanding infiltrates of lymphocytes on fibrocytes. Even in the absence of that change, the findings pictured are those of mycosis fungoides. 11.14.41A: Perivascular dermatosis + 11.14.41B: Lymphocytes around venules,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

…cally (but a tenet basic of histology holds that histiocytes, fibrocytes, and endothelial cells may be indistinguishable from one another morphologically). Furthermore, the appellation histiocytoid hemangioma was intended to specify a single process…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…throughout much of the dermis and sometimes the subcutis 5. Fibrocytes in the upper part of the dermis appear normal, i.e., having oval nuclei and scant cytoplasm 5. Fibrocytes in the upper part of the dermis are abnormal with long tails of cytopla…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…r layer Epidermal changes not prominent Increased number of fibrocytes around the upper part of a follicle, but no concentration of fibrocytes at the isthmus Lamellar fibroplasia at the level of the isthmus Despite these sets of findings seeming…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…d numerous plasma cells surround venules, and histiocytes and fibrocytes in company with thickened bundles of collagen in the reticular dermis = Necrobiosis lipoidica Although the changes pictured fulfill criteria for necrobiosis lipoidica, absent ar…