Differential Diagnosis in Dermatopathology

Alopecia of discoid lupus erythematosus vs. Alopecia of lichen planus

A red, often ulcerated, boggy papule that represents a hyperplasia of small cutaneous vessels which are “fed” by an arteriole in the subcutaneous fat, the lesion resulting consistently from external trauma, usually in the form of a punct…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.1.1A: Fibrosing dermatosis and proliferation of small blood vessels + 11.1.1B: Throughout the reticular dermis, an increased number of thick-walled venules lined by plump endothelial cells, fibrin in the wall of some venules, ex…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

See Fig. 5.239 A-C. Figure 5.239 A-C. Patterns of vesiculation: intraepidermal, subepidermal, and intra- and subepidermal. “Blister” and “vesiculobullous” are terms generic for lesions of the skin that usually are elevated…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.2.1A: Perivascular dermatitis, spongiotic and slightly psoriasiform + 10.2.1B: Slight edema of the papillary dermis and scale-crust = Nummular dermatitis ┬áChanges such as these are indistinguishable from those of allergic contac…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

Dystrophic epidermolysis bullosa Presentation stereotypical Age and sex Infancy, both sexes Distribution of lesions Widespread, but variable according to type of dystrophic epidermolysis bullosa (see Variations clinical) Individual lesions Vesicles,…

Differential Diagnosis in Dermatopathology

Subcutaneous granuloma annulare vs. Rheumatoid nodule

A red, often ulcerated, boggy papule that represents a hyperplasia of small cutaneous vessels which are “fed” by an arteriole in the subcutaneous fat, the lesion resulting consistently from external trauma, usually in the form of a punct…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

See Fig. 5.218 A&B. Figure 5.218 Vasculitis. A. Small vessel. B. Large vessel. Before a reasoned and reasonable method for diagnosis histopathologic of vasculitis in skin and subcutaneous fat can be formulated, a definition of vasculitis must…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

Foreign body reaction Synonyms Foreign body granuloma Presentation stereotypical Age and sex Any age and either sex Distribution of lesions Localized usually Individual lesions Papules, plaques, and nodules Course Longstanding Variations clinical…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

Graft-versus-host disease/Eruption of lymphocyte recovery Presentation stereotypical Age and sex Persons of any age and of both sexes who have received allogeneic bone marrow transplantation, reinfusion of autologous marrow, transplantation of solid…