Differential Diagnosis in Dermatopathology

Discussions

…hinned epidermis and a papillary dermis thickened by delicate fibroplasia, melanophages, a sprinkling of lymphocytes, necrotic keratocytes, and telangiectases. In actuality, the papillary dermis in lesions of lichen planus-like keratosis (and primary…

Differential Diagnosis in Dermatopathology

Alopecia of discoid lupus erythematosus vs. Alopecia of lichen planus

An inflammatory process that develops secondary to trauma, usually in the form of a penetrating injury or rupture of a follicle, and that proceeds through stages of granulation tissue with numerous extravasated erythrocytes, granulomatous inflammati…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…roangiodermatitis ¬†This condition, which is thought to be an expression in the skin of a vascular malformation that originates well beneath the dermis, consists of changes that are a caricature of those of severe stasis coupled with fibroplasia….

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

…y to the effects of them, such as spongiosis, acanthosis, and fibroplasia, that infiltrate being unaffiliated with cells of any other fundamental pathologic process, such as neoplastic, hamartomatous, cystic, etc. As was said in the last edition of…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes Epidermis thinned and sometimes devoid of rete ridges Correlation clinicopathologic Blisters are s…

Differential Diagnosis in Dermatopathology

Subcutaneous granuloma annulare vs. Rheumatoid nodule

An inflammatory process that develops secondary to trauma, usually in the form of a penetrating injury or rupture of a follicle, and that proceeds through stages of granulation tissue with numerous extravasated erythrocytes, granulomatous inflammati…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…clinical. Those white scars are a result of a combination of fibroplasia and loss of melanin from the epidermis secondary to the effects of infarction. There is nothing specific about those “whites” or “off whites.” They may…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

…uum sometimes Foreign bodies detectable sometimes in zones of fibroplasia Attributes histopathologic of foreign bodies common in skin and subcutaneous fat Rupture of an infundibular cyst is recognized by the presence of individual cornified cells…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…lichenoid infiltrate of lymphocytes wanes, it is replaced by fibroplasia. The changes sclerodermatous in chronic graft-versus-host disease are indistinguishable from those of morphea as it is encountered in circumstances as dissimilar as in Shulman&…