Differential Diagnosis in Dermatopathology

Alopecia of discoid lupus erythematosus vs. Alopecia of lichen planus

…ntly from external trauma, usually in the form of a puncture or a yank of a “hang nail.” In time, the proliferation of vessels ceases, there is progressive fibroplasia, and the then gray or white papule shrinks and eventually disappears….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…roangiodermatitis ┬áThis condition, which is thought to be an expression in the skin of a vascular malformation that originates well beneath the dermis, consists of changes that are a caricature of those of severe stasis coupled with fibroplasia….

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…and faulty adhesion between epidermis and dermis by virtue of fibroplasia, most notably a scar, on the other. When serum enters a subepidermal cleft above a scar, a blister comes into being (Fig. 5.301 A&B). Figure 5.298 A&B. Acantholytic…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…dermatitis, spongiotic + 10.2.4B: Lymphocytes, a focus of fibroplasia in the upper part of the dermis, slight acanthosis, hypergranulosis, and compact orthokeratosis = Allergic contact dermatitis, late ┬áThe compact orthokeratosis and hypergranulo…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes Epidermis thinned and sometimes devoid of rete ridges Correlation clinicopathologic Blisters are s…

Differential Diagnosis in Dermatopathology

Subcutaneous granuloma annulare vs. Rheumatoid nodule

…ntly from external trauma, usually in the form of a puncture or a yank of a “hang nail.” In time, the proliferation of vessels ceases, there is progressive fibroplasia, and the then gray or white papule shrinks and eventually disappears….

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…clinical. Those white scars are a result of a combination of fibroplasia and loss of melanin from the epidermis secondary to the effects of infarction. There is nothing specific about those “whites” or “off whites.” They may…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

…uum sometimes Foreign bodies detectable sometimes in zones of fibroplasia Attributes histopathologic of foreign bodies common in skin and subcutaneous fat Rupture of an infundibular cyst is recognized by the presence of individual cornified cells…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…lichenoid infiltrate of lymphocytes wanes, it is replaced by fibroplasia. The changes sclerodermatous in chronic graft-versus-host disease are indistinguishable from those of morphea as it is encountered in circumstances as dissimilar as in Shulman&…