Differential Diagnosis in Dermatopathology

Differential Diagnosis

…0. No dull pink globules within the epidermis as a rule 11. Hyperkeratosis, hypergranulosis, and spinous-cell hyperplasia usual 11. Hyperkeratosis not prominent; no hypergranulosis usually; little epidermal hyperplasia 12. No evidence of regressi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Occlusion Triad?

…es of the follicular occlusion triad appears to be follicular hyperkeratosis leading to retention of follicular products.” Lever WF, Schaumburg-Lever G. Bacterial disease. In: Histopathology of the skin. 7th ed. Philadelphia, PA: JB Lippincott…

Differential Diagnosis in Dermatopathology

Discussions

…ive patterns of epithelium in the skin, such as epidermolytic hyperkeratosis, focal acantholytic dyskeratosis, cornoid lamellation, and epithelial (follicular) mucinosis. When pale-cell acanthosis occurs in a seborrheic keratosis, for example, the le…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s lesion is domed and infundibula display hypergranulosis and hyperkeratosis, it must have been rubbed persistently and forcefully, probably because of effects pruritogenic on nerves of enzymes released from neutrophils. Those effects could be the re…

Differential Diagnosis in Dermatopathology

Discussions

…pillary dermis and the epidermis. Both conditions may display hyperkeratosis, epidermal hyperpigmentation, papillomatosis, melanophages, and an increased number of fibrocytes in a thickened pale-staining papillary dermis. Whereas nevus verrucosus is…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Chondrodermatitis Nodularis Helicis?

…of infundibular epidermis associated with hypergranulosis and hyperkeratosis of infundibula. When animated scratching or analogous trauma supervenes, an erosion or ulceration develops, which is covered by crust. Seated beneath an ulcer or at the base…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cutaneous Horn?

…s, or a solar keratosis (or an acrokeratosis verruciformis, a hyperkeratosis lenticularis, a keratoacanthoma). Squamous papilloma describes the appearance histopathologic of any digitate or nipple-shaped proliferation of squamous epithelium; it is no…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

…d ed. London: Churchill Livingstone. 2004:47. “Nailbed hyperkeratosis may be observed in both SLE and discoid lupus erythematosus (DLE).” Richert B, Andre J, Bourguignon R, de la Brassinne M. Hyperkeratotic nail discoid lupus erythemato…

Differential Diagnosis in Dermatopathology

Pale-cell acanthoma vs. Psoriasis, plaque expression

A keratotic condition of the palms and soles, inherited usually, but sometimes acquired, in which involvement may be diffuse, circumscribed (including striate), or punctate….

Histologic Diagnosis of Inflammatory Skin Diseases

“Kyrle’s disease”

…hat condition (or conditions) he actually described as “hyperkeratosis follicularis et parafollicularis in cutem penetrans,” a title that in itself is daunting and dizzying. It is likely, however, that it was not “follicularis&#8221…