Histologic Diagnosis of Inflammatory Skin Diseases

Definition of Inflammation in Historical Perspective

…mental manifestations of disease, the others being neoplasia, hyperplasia, hamartoma, malformation, degeneration, and cyst. With regard to the skin, Ferdinand Hebra, in the third volume of Virchow’s Handbook of Special Pathology and Therapy pub…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…217;s disease: splenohepato-megaly associated with widespread hyperplasia of nonlipoid-storing macrophages; discussion of the so-called reticule-endothelioses. Am J Dis Child 1936;51(3):499–522. “This paper deals with a peculiar and hit…

Dermatology Practical & Conceptual

A verrucous plaque on the lower leg

…verrucous plaque. Histopathologic findings revealed epidermal hyperplasia and papillomatosis. Granulomas were noted in the dermis showing central suppuration and necrosis (Figure 2). A marked plasma cell infiltrate was also evident. Copper colored mu…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Tricho-, pilo-, folliculo- ?

…bulb. In short, tricholemmoma is not a benign neoplasm, but a hyperplasia. “Tricho-” is applied correctly in the name trichotillomania, in which hair shafts are twisted to and fro until they break, and it also is used properly in the term…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…perficial perivascular dermatitis + spongiosis + psoriasiform hyperplasia = spongiotic psoriasiform dermatitis (allergic contact or nummular dermatitis, fully developed). Figure 5.4 Contents of Histologic Diagnosis of Inflammatory Skin Diseases: A…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

…erans is manifested by endothelial cell swelling, endothelial hyperplasia and expansion of vessel walls by edema and a lymphohistiocytic infiltrate with luminal attenuation.” Barnhill RL. The treponemal and rickettsial diseases. In: Barnhill R…