Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…ariable number of extravasated erythrocytes = Gianotti-Crosti syndrome + Wedge-shaped infiltrate, strikingly atypical lymphocytes, and some lymphocytes often in mitosis = Lymphomatoid papulosis + Nodular or diffuse infiltrate of abnormal lymphocy…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…dermis, and ballooned and necrotic keratocytes = Toxic shock syndrome Because of edema in the upper part of the dermis and of spongiosis, this lesion can be told to be evolving still, although the psoriasiform acanthosis indicates that already its a…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…lookalikes, bullous impetigo and staphylococcal scalded skin syndrome, in which the epidermis above the blister was lost during the biopsy itself, in the bottle of formalin, or in the course of processing the tissue. Despite the lack of specificity…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…mopathy is analogous, if only vaguely, to tryptophane-myalgia syndrome, toxic oil syndrome, and Shulman’s syndrome (see Fig. 5.361 A&B), each of those conditions being authentic morphea in response to a precipitating factor that is identifi…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…#651) Mycosis fungoides (Quiz #652) Mycosis fungoides (Sézary syndrome) (Quiz #210) Mycosis fungoides (small-plaque parapsoriasis) (Quiz #160) Mycosis fungoides, alopecia mucinosa type (Quiz #110) Mycosis fungoides, altered histopathologically by vir…

Histologic Diagnosis of Inflammatory Skin Diseases

Pyoderma gangrenosum

…vitable. Differential diagnosis histopathologic Sweet’s syndrome consists of nodular infiltrates of neutrophils, marked edema of the papillary dermis, and an intact epidermis, but it is not associated with suppurative infundibulitis. Sometimes…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Subacute Cutaneous Lupus Erythematosus?

…s lupus erythematosus and annular erythema of Sjogren’s syndrome suggest that these two skin diseases might arise from a similar pathogenic process.” McCauliffe DP, Faircloth E, Wang L, Hashimoto T, Hoshino Y, Nishikawa T. Similar Ro/SS-…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Myxoma?

…omas are rare tumours which may be associated with a systemic syndrome, which includes cardiac myxomas as one of its manifestations.” Weedon D. Tumors of fibrous tissue. In: Weedon D, ed. The Skin. Edinburgh, Scotland: Churchill-Livingstone, 1…