Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Overlap Syndromes?

…used to seeing in a single specimen of tissue both seborrheic keratosis and verruca vulgaris, both seborrheic keratosis and Bowen’s disease, and both seborrheic keratosis and basal-cell carcinoma. Very rarely, that may be true for seborrheic d…

Differential Diagnosis in Dermatopathology

Discussions

Seborrheic keratosis of the acanthotic type and eccrine poroma are both benign, epithelial, exo-endophytic neoplasms comprised mostly of small, round (basaloid) cells. Melanocytes may be scattered among keratocytes in both conditions. Seborrheic ker…

Histologic Diagnosis of Inflammatory Skin Diseases

Definition of Inflammation in Historical Perspective

…capable of inducing an inflammatory response, e.g., seborrheic keratosis that in the face of an infiltrate of lymphocytes becomes a lichen planus-like keratosis and a certain kind of compound melanocytic nevus that, consequent to effects of lymphocyt…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…benign neoplasms (two examples already cited being seborrheic keratosis, especially in the form of lichen planus-like keratosis, and a particular melanocytic nevus in the form of halo nevus) are associated with dense infiltrates of inflammatory cell…

Differential Diagnosis in Dermatopathology

Discussions

Darier’s disease and Grover’s disease have several findings histopathologic in common, among them foci of acantholytic dyskeratotic cells in the epidermis and a superficial perivascular infiltrate of inflammatory cells, usually lymphocyt…