Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Anagen Effluvium?

…, 1999:736. “A 32 year-old woman developed generalised lichenoid eruptions on her body followed by diffuse loss of scalp hair of the anagen effluvium type. She was receiving several anti-tubercular drugs, including rifampicin, isonicotinic aci…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…ty of interface “dermatitides,” especially “lichenoid” ones, that are associated with nonviable keratocytes referred to in times past as Civatte bodies, colloid bodies, and hyaline bodies (pathologic cell death). Those bodies,…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen simplex chronicus/Prurigo nodularis/Picker’s nodule/Erosions/Ulcers

…thesis holds that globules of amyloid in macular and papular (lichenoid) amyloidosis represent necrotic keratocytes that have formed secondary to excoriation and that have been transformed in dermal papillae into what is called amyloid after they hav…

Differential Diagnosis in Dermatopathology

Insect "bite" vs. Lymphomatoid papulosis

A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a syst…

Differential Diagnosis in Dermatopathology

Discussions

…present in lichen nitidus. The combination of spongiosis and lichenoid granulomatous inflammation is unique to lichen striatus. Those features, in conjunction with the others listed in the columns at the beginning of this chapter, enable lichen niti…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…homatoid papulosis. 11.13.11A: Perivascular dermatosis, lichenoid, with severe subepidermal edema + 11.13.11B: Strikingly atypical lymphocytes, some of them in mitosis, in league with small lymphocytes = Lymphomatoid papulosis  The abnormal…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…ense enough or sufficiently band-like to be considered “lichenoid.” Nonetheless, by following the algorithm for “interface dermatitis” and pursuing either route, i.e., vacuolar or lichenoid, a histopathologist should be able t…

Histologic Diagnosis of Inflammatory Skin Diseases

Herpes gestationis

…tionis is nearly specific for those disorders. A psoriasiform lichenoid pattern or a spongiotic psoriasiform lichenoid pattern composed of lymphocytes and eosinophils also may be observed episodically in urticarial lesions of bullous pemphigoid and h…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…itis, infundibular, and perivascular dermatitis, psoriasiform lichenoid + 10.17.14B: Preponderance of neutrophils in the lichenoid infiltrate = Infection by atypical mycobacteria Acid-fast stain reveals countless bacilli in zones of suppuration i…

Histologic Diagnosis of Inflammatory Skin Diseases

Tuberculosis verrucosa cutis

…indings histopathologic Fully developed Granulomas dotting a lichenoid infiltrate of lymphocytes and plasma cells Beneath the zone of lichenoid lymphoplasmacytic infiltration, discrete granulomas surrounded by numerous lymphocytes and plasma cells M…