Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Halo Phenomenon?

…various kinds; (3) histopathologically, for an infiltrate of lymphocytes within the substance of a melanocytic nevus that clinically is devoid of a halo of depigmentation; and (4) clinically, for a zone of hypo- or depigmentation that represents a m…

Differential Diagnosis in Dermatopathology

Discussions

…hare some findings histopathologic, including the presence of lymphocytes as solitary units, as well as in collections, in the epidermis, spongiosis, acanthosis at times, parakeratosis in which serum resides, and a perivascular infiltrate in which ly…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen sclerosus et atrophicus

…histopathologic Early Superficial perivascular infiltrate of lymphocytes Patchy lichenoid infiltrate of lymphocytes in conjunction with vacuolar alteration obscuring the dermoepidermal junction Markedly altered, pale collagen in the papillary dermis…

Differential Diagnosis in Dermatopathology

Discussions

…in the upper part of the dermis, it often containing abnormal lymphocytes and episodically eosinophils. Many of the abnormal lymphocytes have cerebriform nuclei. Mitotic figures may be seen within lymphocytes. For these reasons, distinguishing histop…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….111.1A: Perivascular dermatitis, mixed-cell + 10.111.1B: Lymphocytes, eosinophils, and a few neutrophils around venules = Urtica, early ┬áThis is an early stage in the evolution of urticaria because inflammatory cells are huddled around venules;…

Histologic Diagnosis of Inflammatory Skin Diseases

Polymorphous light eruption

…uperficial or superficial and deep perivascular infiltrate of lymphocytes Fully developed Moderately dense superficial and deep perivascular infiltrate of lymphocytes Marked edema of the papillary dermis Subepidermal vesiculation secondary to edema…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…Fully developed Dense patchy or diffuse infiltrates of small lymphocytes, plasma cells, neutrophils, eosinophils, and abnormal lymphocytes in lobules of the subcutaneous fat; some abnormal lymphocytes in mitosis common Phagocytosis of erythrocytes (…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Parapsoriasis?

…lesions are characterized by patchy lichenoid infiltrates of lymphocytes associated with wiry bundles of collagen arrayed haphazardly in the upper part of the dermis, by an epidermis peppered in loci by lymphocytes in conjunction with scant spongios…