Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Precursor Lesions of Melanoma?

…inson’s melanotic freckle), is an irregularly pigmented macule which expands slowly.” Weedon D. Lentigines, nevi and melanomas. In: Skin Pathology. 2nd ed. London: Churchill Livingstone, 2002:822-823. “Such precursor lesions may i…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…iphery and without a characteristic shape. Individual lesions Macules, patches, papules, and plaques, often scaly to varying extent, sometimes tending to display wrinkling of the surface in a manner that has been likened to that of cigarette paper; i…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Dermatofibrosarcoma protuberans

An arteritis in the subcutaneous fat manifested clinically at first by one or more red nodules that, in time, become ulcerated and heal with scars, usually on the posterior aspect of the legs of short, thick-legged women. No cause is usually found,…

Differential Diagnosis in Dermatopathology

Pyogenic granuloma, fully developed vs. Kaposi’s sarcoma, nodular

An arteritis in the subcutaneous fat manifested clinically at first by one or more red nodules that, in time, become ulcerated and heal with scars, usually on the posterior aspect of the legs of short, thick-legged women. No cause is usually found,…

Dermatology Practical & Conceptual

Review of Atlas of Vulvar Pathology. 3rd ed. by EJ Wilkinson, IK Stone

…y can present as a papular lesion, but it can also occur as a macule, a plaque or an ulcer and it certainly is a malignant tumor. Another evident flaw in this classification is exemplified by verrucous carcinoma, which is addressed in the chapter on…

Histologic Diagnosis of Inflammatory Skin Diseases

Vitiligo

…segmental, or widespread; often symmetric Individual lesions Macules and patches Course Protracted usually, but repigmentation occurring at times from melanocytes situated in infundibula Variations clinical Association, episodically, with alopecia…

Differential Diagnosis in Dermatopathology

Discussions

…s by progressive fibrosis. Kaposi’s sarcoma begins as a macule or patch that is characterized histopathologically by an increase in number of endothelium-lined spaces with jagged outlines that form around normal venules of the pre-existing supe…

Differential Diagnosis in Dermatopathology

Discussions

…igmentation of the epidermis is striking; and resolution as a macule characterized by hypopigmentation in the center and hyperpigmentation at the periphery when the lesion has constricted as a consequence of the effects of fibroplasia longstanding an…

Differential Diagnosis in Dermatopathology

Discussions

…fibroma), but when it resolves without treatment it becomes a macule with a round central zone of hypopigmentation and a rim of hyperpigmentation. If the inflammatory process is restricted to the mid-reticular dermis or below it, follicular or sebace…