Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

…nocytic nevus, so-called nevus cells that really are abnormal melanocytes. If the word nevus is abstruse, then nevoid (or nevic) is opaque. And what of the words “mucoid” and “myxoid,” as in the cyst that lacks a lining of epi…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

…to be separated from adjacent keratocytes by a cleft, just as melanocytes are separated from keratocytes by a space, a finding that for more than a century caused them to be interpreted incorrectly as “high-level melanocytes.” In fact, th…

Dermatology Practical & Conceptual

When all you have is a dermatoscope—start looking at the nails

…eatening diseases are possible underlying causes. Nail matrix melanocytes of unaffected individuals are in a dormant state, and, therefore, fingernails and toenails physiologically are non-pigmented. The formation of continuous, longitudinal pigmente…

Histologic Diagnosis of Inflammatory Skin Diseases

Merkel Cells

…pear in fetal skin by the 16th week of gestation, and, unlike melanocytes, they do not come from the neural crest, and, unlike Langerhans” cells, they do not come from the bone marrow; they originate in the epidermis itself, presumably from ger…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

….36 A&B), the so-called nevus cells really being abnormal melanocytes. Figure 5.35 A&B. Simulation of an inflammatory disease. A perivascular lymphoplasmacytic infiltrate, such as this, could be misconstrued as that of a dermatitis, e.g.,…

Histologic Diagnosis of Inflammatory Skin Diseases

Tinea nigra

…the cornified layer of benign and malignant proliferations of melanocytes. Stain of skin by silver nitrate has an unnatural appearance because it is caused artifactually. It can be scraped off because the discoloration resides in the outer part of th…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…, sebaceous units, apocrine units, eccrine units, nail units, melanocytes, Langerhans” cells, Merkel cells, structures of the dermoepithelial interface, blood vessels, lymphatics, collagen, elastic fibers, ground substance, muscles, and nerves….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Borderline, Minimal Deviation, and Nevoid Melanomas?

…iation melanoma have been described . . . A small nodule of melanocytes that show moderate to moderately severe atypism and impinge on the reticular dermis . . . Minimal deviation melanomas that share some histologic features with a Spitz tumor. Ha…