Dermatology Practical & Conceptual

Regression of nevi in a melanoma patient treated with interferon

Background High-risk melanoma patients are occasionally offered adjuvant treatment with interferon alpha 2b as a postsurgical treatment. This treatment is thought to improve disease-free survival by upgrading immunomodulatory functions, which cause…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Histologic Diagnosis of Inflammatory Skin Diseases

Merkel Cells

In 1875, Friedrich Merkel, a 30-year-old physician at the University of Rostock in Germany, noted unique cells at the base of epidermal rete ridges, those cells being in contact with nerve fibers. He considered the cell-neurite complexes to be touch…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

Capability for accurate diagnosis of inflammatory skin diseases, clinically and histopathologically, requires familiarity thoroughly with embryologic, histologic, and anatomic aspects of the skin. Although examples of this precept are legion, only a…

Histologic Diagnosis of Inflammatory Skin Diseases

Tinea nigra

Tinea nigra Synonyms Tinea nigra palmaris Keratomycosis nigricans palmaris Pityriasis nigra Carate noir Montoyola nigra Presentation stereotypical Age and sex Young persons especially and of both sexes Distribution of lesions Volar skin, a palm most…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Borderline, Minimal Deviation, and Nevoid Melanomas?

“Borderline lesions are encountered in other organ systems. In the category of epithelial neoplasms of the ovary, borderline lesions are common. They are also commonly manifested as papillary lesions of the breast.” Reed RJ. Minimal de…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophie Blanche?

“In any event, it is a special form of cutaneous atrophy in its presentation, a real idiopathic malady, i.e., if you do not wish to attribute it to syphilis, [and] we designate it ‘atrophie blanche.’ … Histologic examination…

Clinical Case Studies

Nevus of Ota

INITIAL PRESENTATION A 32-year-old Asian man presented with a long-standing patch of gray-brown discoloration under his left eye. (Figure 1) He noted an increasing prominence of the pigmentation over the preceding 15 years. The patient had a history…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

General Balkwill F (ed). Cytokine Cellular Biology: A Practical Approach (Practical Approach Series). Oxford: Oxford University Press, 2000. Darmon M, Blumenberg M (eds). Molecular Biology of the Skin: The Keratinocyte. San Diego: Academic Press, 19…