Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Site

…ed not to perform a biopsy on excoriated lesions, indubitable scars, or postinflammatory pigmentary changes because those lesions usually provide no clue to the exact nature of the original inflammatory disease. Studying sections from “burned o…

Histologic Diagnosis of Inflammatory Skin Diseases

Burns

…neocytes, incapable of responding to any stimulus. Atrophic scars induced by a burn, granuloma inguinale, chronic radiodermatitis, and lupus vulgaris are loci with potential for development of carcinomas, especially squamous-cell carcinoma. Last,…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…ons Course Individual lesions heal in weeks, usually without scars; process persists for a lifetime. No association with mental retardation in most expressions of it Variations clinical Epidermolytic epidermolysis bullosa Köbner type (epidermolysis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

…pyoderma-like lesions or painful granulomas in postoperative scars [have] also been described.” Mangold MC, Callen JP. Cutaneous leukocytoclastic vasculitis associated with active Wegener’s granulomatosis. J Am Acad Dermatol 1992;26:582…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Erythema Dyschromicum Perstans?

…on changes histopathologic is not unique. It is true also for scars, keloids, and dermatofibromas, all of which are fibrosing inflammatory processes that examination by conventional microscopy fails almost always to inform about in regard to an incit…

Clinical Case Studies

Extensive Actinic Damage

…s squamous cell carcinoma with resultant well-healed surgical scars on his forehead, nose, and cutaneous upper lip. On examination, numerous scaly erythematous plaques were evident on his face and scalp. Over the preceding three years, the patient ha…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Fibromatoses?

…e are fibrosing inflammatory processes (peculiar hypertrophic scars), Hügel’s plaque-like dermal fibromatosis is a connective tissue nevus (of myofibrocytes), and desmoid tumor is a malignant neoplasm (“low grade” sarcoma). General…

Differential Diagnosis in Dermatopathology

Acne vulgaris, erythematous papule vs. Rosacea, erythematous papule

Alterations in the skin and subcutaneous fat, such as pigmentation and induration, secondary to the effects of long-term stasis, and ulcers that occur on the lower part of the legs as a consequence of the effects, combined, of incompetent valves of…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…disease, has significance for diagnosis clinical. Those white scars are a result of a combination of fibroplasia and loss of melanin from the epidermis secondary to the effects of infarction. There is nothing specific about those “whites”…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…the latter manifested clinically as a scar. The appearance of scars that follow on suppurative infundibulitis of acne vulgaris varies; it ranging from “ice pick” atrophic ones to hypertrophic ones. 10.37.6A: Pustular dermatitis, inf…