Histologic Diagnosis of Inflammatory Skin Diseases

Dermatitis herpetiformis

Dermatitis herpetiformis Synonyms During-Brocq disease Duhring’s disease Presentation stereotypical Age and sex Begins usually in young adults, but may appear for the first time in children or in middle-aged persons; no predilection for eith…

Histologic Diagnosis of Inflammatory Skin Diseases

Junctional epidermolysis bullosa

Junctional epidermolysis bullosa Presentation stereotypical Age and sex Onset at birth in both sexes Distribution of lesions Widespread Individual lesions Vesicles, bullae, and vegetating crusts atop ulcers Course Blisters heal with slight scarring….

Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Site

Because many inflammatory diseases of the skin, e.g., dermatitis herpetiformis, nummular dermatitis, scabies, Grover’s disease, and eosinophilic folliculitis, are exquisitely pruritic, scratching is an inevitable consequence, and signs of exco…

Histologic Diagnosis of Inflammatory Skin Diseases

Burns

Burns Synonyms Thermal injuries Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Regions that usually are exposed rather than covered Configuration of lesions Depends on the particular type of burn; bizarre shape…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

Epidermolysis bullosa simplex Presentation stereotypical Age and sex Shortly after birth or during childhood and adolescence; both sexes affected Distribution of lesions Varies according to type of epidermolysis bullosa (see Variations clinical) Ind…

Differential Diagnosis in Dermatopathology

Discussions

Mucha-Habermann disease and lymphomatoid papulosis have several features clinical in common, among those being papules and papulovesicles that erupt in crops in persons of all ages. Histopathologically, both diseases are characterized by wedge-shape…

Differential Diagnosis in Dermatopathology

Acne vulgaris, erythematous papule vs. Rosacea, erythematous papule

Alterations in the skin and subcutaneous fat, such as pigmentation and induration, secondary to the effects of long-term stasis, and ulcers that occur on the lower part of the legs as a consequence of the effects, combined, of incompetent valves of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

“With the high power the hyaline is seen in very varied forms, which all show the same fuchsin red reaction. The first forms a section by itself; it comprises hyaline balls of different size, which lie free between the epithelial cells, and w…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

“Inside the nose besides extensive necrosis, there is a cell-rich granulomatous tissue with granulomatous epithelioid cell foci which surround the vessels. . . . In both lungs: infarct-like necrosis in which one finds severe changes in the ve…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Fibromatoses?

“Benign tumors and tumor-like proliferations Fibromatoses Fibroma molle Nonmetastasizing fibrosarcomas Desmoid tumor Keloid Cicatricial fibromatosis Palmar fibromatosis (fibroma or pseudotumor of Dupuytren’s contracture) Plantar fibroma…