Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…mis and subcutaneous fat. Histiocytosis X (Langerhans” cell histiocytosis) consists of a dense infiltrate of abnormal Langerhans” cells characterized by large, pale, reniform nuclei and abundant amphophilic cytoplasm, many eosinophils,…

Differential Diagnosis in Dermatopathology

Granular-cell tumor vs. Xanthoma

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…

Differential Diagnosis in Dermatopathology

Pale-cell acanthoma vs. Psoriasis, plaque expression

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…

Differential Diagnosis in Dermatopathology

Trichoadenoma vs. Microcystic adnexal carcinoma

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…

Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma? In 1970, large cell acanthoma (LCA) was first described by Pinkus, as a sharply demarc…

Differential Diagnosis in Dermatopathology

Lymphocytoma cutis with lymphoid follicles vs. Follicular-cell lymphoma

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…