Search Results for: x-linked ichthyosis

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen sclerosus et atrophicus

…anulosis, and sometimes acanthosis. When lichen sclerosus et atrophicus affects the penis, the condition is termed balanitis xerotica obliterans, an example of superfluous synonymy, along with Bowen’s disease and erythroplasia of Queyrat and…

Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

…time in Darier’s disease) and the age of onset (usually older individuals in Grover’s disease, i.e., fifth and sixth decades of life especially). Grover’s disease unlike Darier’s disease, is not transmitted in an autosomal…

Histologic Diagnosis of Inflammatory Skin Diseases

Keratosis pilaris/Lichen spinulosus

…reputed to be widespread “follicular” papules topped by large scale-crusts; lesions are said to occur mostly on extensor surfaces of extremities and in women especially; whether Kyrle’s disease deserves being regarded as having…

Differential Diagnosis in Dermatopathology

Nevus verrucosus vs. Acanthosis nigricans

…apes, e.g., (round, ellipsoid, and arcuate) (erythema chronicum migrans), pseudolymphomatous nodules (lymphadenosis benigna cutis), and acral patches and plaques that in time become atrophic (acrodermatitis chronica atrophicans). It may express…

Two neutrophilic dermatoses captured simultaneously on histology

Two neutrophilic dermatoses captured simultaneously on histology

…wer view of neutrophils within the dermis. Note the absence of vasculitis. Hematoxylin and eosin, original magnification (a) x40 (b) x100. [Copyright: ©2016 Wlodek et al.] Figure 2. (a) High power view of neutrophilic infiltration of eccrine sweat…

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis chronica atrophicans

…icans Presentation stereotypical Age and sex Middle aged to elderly women especially Distribution of lesions Distal part of extremities, particularly of legs; nodules develop especially near knees and elbows Configuration of lesions Extension of…

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

…n the blister cavity, multinucleated keratinocyte giant cells with nuclear molding are also noted (hematoxylin and eosin; a= x4, b=x20, c=x40). (Copyright: ©2014 Cohen et al.) The clinical features and improvement with topical corticosteroid therapy…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…pping for mutations in the Xp I I.21 or the Xq28 locus. Cause and mechanism This hereditary systemic disease is caused by an Xlinked genetic defect in loci Xp I I.21 or Xq28, which is dominant in females and usually lethal in males. The mechanism…