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Histologic Diagnosis of Inflammatory Skin Diseases

Images

…manifestations clinical of livedo vasculitis are purpuric macules and patches. They may be followed by blisters secondary to ballooning and spongiosis, and then by ulcers. When the process resolves with fibrosis, as it does in the course of many…

Histologic Diagnosis of Inflammatory Skin Diseases

Livedo vasculitis

…or more venules Many erythrocytes extravasated in the upper part of the dermis Edema of the papillary dermis Spongiosis and ballooning sometimes resulting in intraepidermal vesiculation Epidermis necrotic often Late Sparse infiltrate of lymphocytes…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Subcorneal Blistering Diseases?

…analogous situation obtains in some intraepidermal blistering diseases typified either by extensive spongiosis or inordinate ballooning. An example of the former is severe allergic contact dermatitis that begins as intraepidermal vesicles that, in…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…lteration, a smudged appearance of that junction, a thickened basement membrane), in the viable epidermis (e.g., spongiosis, ballooning, acantholysis), and/or in the cornified layer (e.g., parakeratosis in mounds that house neutrophils,…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…l (basket-woven, laminate, and compact orthokeratosis) 2. Intra-epidermal vesiculation 2. No intra-epidermal vesiculation 3. Ballooning of keratocytes 3. No ballooning of keratocytes 4. Reticular alteration of the epidermis 4. No reticular…

Differential Diagnosis in Dermatopathology

Discussions

…, individual necrotic keratocytes in the surface epidermis and upper portion of epithelial structures of adnexa, spongiosis, ballooning, lymphocytes contiguous to many necrotic keratocytes, clusters of necrotic keratocytes in the surface epidermis…

Differential Diagnosis in Dermatopathology

Discussions

…r in the upper part of the dermis. Both diseases often display parakeratosis, necrosis of epidermal keratocytes, spongiosis, ballooning, and edema of the papillary dermis. The major difference between the two very unalike processes pathologic is…

Differential Diagnosis in Dermatopathology

Discussions

…the papillary dermis, edema of the papillary dermis, more necrotic keratocytes and even confluent necrosis of the epidermis, ballooning, intraepidermal vesiculation, and neutrophils in zones of parakeratosis. Each of those findings signals a process…

Histologic Diagnosis of Inflammatory Skin Diseases

Staphylococcal scalded skin syndrome

…n being present in the blister. In contrast, the blister in erythema multiforme may develop in the spinous zone secondary to ballooning and spongiosis or at the dermoepidermal junction consequent to the effects of extensive vacuolar alteration; at…