Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…asement membrane), in the viable epidermis (e.g., spongiosis, ballooning, acantholysis), and/or in the cornified layer (e.g., parakeratosis in mounds that house neutrophils, scale-crusts, hyphae). In regard to blistering diseases, an algorithm that a…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…c vasculitis began intraepidermal consequent to extraordinary ballooning of keratocytes and ended subepidermal as a result of the tense intraepidermal blister having exploded. All of the changes in the epidermis are secondary to infarction consequent…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…as a rule solely by spongiosis. This example is exceptional; ballooning is present as well as spongiosis. 10.50.5A: Perivascular dermatitis, psoriasiform + 10.50.5B: Many dyskeratotic cells, some of them in clusters, in the spinous, granul…

Histologic Diagnosis of Inflammatory Skin Diseases

Behçet’s Disease

…some lesions Intraepidermal vesicles sometimes, secondary to ballooning Ulceration episodic secondary to vasculitis Correlation clinicopathologic Acneiform papules are not like those of acne vulgaris because they are not always those of suppurative…

Differential Diagnosis in Dermatopathology

Discussions

…upper portion of epithelial structures of adnexa, spongiosis, ballooning, lymphocytes contiguous to many necrotic keratocytes, clusters of necrotic keratocytes in the surface epidermis especially, and an infiltrate composed almost wholly of lymphocyt…

Dermatology Practical & Conceptual

Balloon cell melanoma in primary care practice: a case report

…studies [12] and electron microscopy, which revealed that the ballooning change was due to progressive vacuolisation of melanosomes [13,14,15]. BCMM is characterised by aggregations of balloon cells [3], and Kao defined BCMM as a melanoma composed of…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…pidermal vesiculation 2. No intra-epidermal vesiculation 3. Ballooning of keratocytes 3. No ballooning of keratocytes 4. Reticular alteration of the epidermis 4. No reticular alteration 5. Confluent necrosis of epidermal keratocytes 5. No confl…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Subcorneal Blistering Diseases?

…iseases typified either by extensive spongiosis or inordinate ballooning. An example of the former is severe allergic contact dermatitis that begins as intraepidermal vesicles that, in time, explode and thereby become subepidermal blisters, too. An e…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…junction by lymphocytes and vacuolar alteration, spongiosis, ballooning, and parakeratosis = Lichen striatus  The infiltrate of lymphocytes in the dermis follows, in linear fashion, vessels of the periadnexal dermis, a finding typical of lichen stri…