Differential Diagnosis in Dermatopathology

Lymphocytoma cutis with lymphoid follicles vs. Follicular-cell lymphoma

An inflammatory disease caused by Mycobacterium leprae. It can involve internal organs or be localized to the skin, where its clinical presentation is dependent on the immunologic status of the host. Persons who are competent immunologically have pa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nuclear Atypia, Cytoplasmic Atypia, and Architectural Atypia?

“The cytologically atypical melanocytes have the same features as cytologically atypical cells in any neoplastic system. Such cells are larger than normal melanocytes or the intraepidermal melanocytes of an ordinary melanocytic nevus.”…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Occlusion Triad?

“The follicular occlusion triad: (acne conglobata, hidradenitis suppurativa, and dissecting cellulitis of the scalp). These diseases comprise a generic group. Though not usually classified together, there is reason to believe that they are…

Histologic Diagnosis of Inflammatory Skin Diseases

Silica granuloma

Silica granuloma Presentation stereotypical Age and sex No predilection Distribution of lesions On exposed sites usually Individual lesions Papules and nodules Course Protracted because the foreign body persists in the skin Findings histopathologic…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

“With the high power the hyaline is seen in very varied forms, which all show the same fuchsin red reaction. The first forms a section by itself; it comprises hyaline balls of different size, which lie free between the epithelial cells, and w…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

“On the basis of clinical, histological, and cellular kinetic observations, a separation of the major ichthyosiform dermatoses into four groups is proposed. Ichthyosis vulgaris patients have dry skin and fine scales on their trunk and extremi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

“An irreversible alopecia of the scalp occurs in negro women who straighten their hair with hot combs. The disease is common and distinctive, clinically and histopathologically. . . . Hot petrolatum used with the comb causes a chronic inflamm…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.63.1A: Perivascular dermatitis, interface, vacuolar + 10.63.1B: Smudged appearance of the dermoepidermal junction, focally thinned epidermis, and plentiful mucin throughout the dermis = Lupus erythematosus, discoid ┬áThe presence…