Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Necrobiosis lipoidica

An inflammatory disease caused by Mycobacterium leprae. It can involve internal organs or be localized to the skin, where its clinical presentation is dependent on the immunologic status of the host. Persons who are competent immunologically have pa…

Differential Diagnosis in Dermatopathology

Discussions

…l attributes histopathologic in common, namely, a nodular and diffuse infiltrate made up mostly of lymphocytes in company with structures that resemble lymphoid follicles, the infiltrate affecting the dermis mostly but, at times, the subcutaneous fat…

Differential Diagnosis in Dermatopathology

Xanthogranuloma vs. Necrobiotic xanthogranuloma

An inflammatory disease caused by Mycobacterium leprae. It can involve internal organs or be localized to the skin, where its clinical presentation is dependent on the immunologic status of the host. Persons who are competent immunologically have pa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nuclear Atypia, Cytoplasmic Atypia, and Architectural Atypia?

…me features as cytologically atypical cells in any neoplastic system. Such cells are larger than normal melanocytes or the intraepidermal melanocytes of an ordinary melanocytic nevus.” Clark WH Jr., Elder DE, Guerry IV D. Dysplastic nevi and m…

Histologic Diagnosis of Inflammatory Skin Diseases

Silica granuloma

…lasm, whereas silicone is finely vacuolated and calls forth a diffuse infiltrate of histiocytes that have foamy cytoplasm. Whenever a histopathologist encounters a sarcoidal granuloma in the skin, silica must be considered in the differential diagno…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…sic discoid lupus erythematosus. 10.63.40A: Nodular and diffuse dermatitis, superficial + 10.63.40B: Neutrophils predominant in association with degenerated bundles of collagen = Lupus erythematosus or rheumatoid arthritis  The changes pict…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…ot those of scarring secondary to a burn; the fibrosis is not diffuse across at least the upper part of the dermis, altered bundles of collagen are not oriented parallel to the skin surface, and venules are not disposed perpendicular to it. Moreover,…