Differential Diagnosis in Dermatopathology

Discussions

…titial, mixed-cell infiltrate of lymphocytes, neutrophils, and eosinophils around blood vessels and neutrophils and eosinophils in the interstitium. In very early lesions, neutrophils may be situated mostly around venules. In later lesions in which e…

Differential Diagnosis in Dermatopathology

Discussions

…nflammatory cells in photoallergic dermatitis may contain many eosinophils, but practically no neutrophils, whereas the infiltrate in phototoxic dermatitis contains neutrophils, but not eosinophils. In later lesions of photoallergic dermatitis, but n…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

10.97.1A: Perivascular and interstitial dermatitis + 10.97.1B: Neutrophils, eosinophils, lymphocytes, and plasma cells in the interstitium of the reticular dermis = Morphea, early ┬áThe changes shown represent an early stage in a longstand…

Histologic Diagnosis of Inflammatory Skin Diseases

Acquired epidermolysis bullosa

…phils in the papillary dermis, sometimes in company there with eosinophils Neutrophils and vacuolar alteration along the dermoepidermal junction Fully developed Mixed-cell infiltrate of neutrophils, eosinophils, and lymphocytes around venules of th…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Urticaria Urticarial lesions of bullous pemphigoid 1. Infiltrate of inflammatory cells usually sparse 1. Infiltrate of inflammatory cells usually moderately dense 2. Infiltration of inflammatory cells spares the papillary dermis and the epider…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema elevatum diutinum

Erythema elevatum diutinum Presentation stereotypical Age and sex Any age, but usually young adults, women especially Distribution of lesions Symmetrical over joints especially, particularly the dorsa of the hands and the elbows and knees Shape of l…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.14.1A: Perivascular dermatosis, psoriasiform lichenoid + 11.14.1B: Lymphocytes, sparse in both the dermis and epidermis, larger in the epidermis than in dermis, solitary in the basal layer in foci, and in association with scant…