Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

…ten in company with variable numbers of lymphocytes and a few eosinophils. “Extravascular necrotizing granulomas” were said to have come into being if the wall of a vessel was destroyed by vasculitis. An extravascular granuloma consisted…

Differential Diagnosis in Dermatopathology

Discussions

…perivascular and interstitial mixed-cell infiltrates in which eosinophils are prominent in the interstitium and lymphocytes around venules. The cardinal signs that enable the differentiation of urticaria from urticarial lesions of bullous pemphigoid…

Differential Diagnosis in Dermatopathology

Discussions

…In an early lesion, an infiltrate consists of lymphocytes and eosinophils that are disposed around venules of the superficial plexus and between bundles of collagen. The papillary dermis usually is edematous, and a few erythrocytes may be extravasate…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ular and interstitial dermatitis + 10.97.1B: Neutrophils, eosinophils, lymphocytes, and plasma cells in the interstitium of the reticular dermis = Morphea, early  The changes shown represent an early stage in a longstanding inflammatory process,…

Histologic Diagnosis of Inflammatory Skin Diseases

Acquired epidermolysis bullosa

…variable density, within which are neutrophils and sometimes eosinophils, in addition to lymphocytes Edema of the papillary dermis Sprinkling of neutrophils and nuclear “dust” of neutrophils in the papillary dermis, sometimes in company…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…marked in foci 5. No inflammatory cells in the epidermis 5. Eosinophils and sometimes lymphocytes in the epidermis commonly, accompanied there by spongiosis 6. No vacuolar alteration along the dermoepidermal junction 6. Vacuolar alteration along…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema elevatum diutinum

…scattered interstitially in the upper half of the dermis; few eosinophils and lymphocytes present around venules Fibrin in the wall of some venules in the zone of infiltration by inflammatory cells Papillary and periadnexal dermis mostly spared Full…