Differential Diagnosis in Dermatopathology

Differential Diagnosis

…st of neutrophils,” basophilia of collagen bundles, and fibrin at the tip of dermal papillae are present beneath and at the sides of a blister 5. No neutrophils, basophilia of collagen, or fibrin at the tip of dermal papillae at the sides of a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

…in, when developed fully, is characterized by the presence of fibrin in the wall of vessels, thrombi in the lumen of vessels, or both together in the context of an infiltrate of inflammatory cells. The definition of vasculitis of small vessels in ski…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg

…dust of neutrophils is present but there is no deposition of fibrin in the vessel walls. Fibrosis is seen in the deeper dermis. In the absence of clinical information, the best interpretation of the changes in this section is pyoderma gangrenosum. T…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…enous, in which the fully developed stage is characterized by fibrinoid necrosis and inflammation involving all three layers of vessel walls. Five distinct types of lesions of this nature are now recognized and can be differentiated morphologically a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

…as a hedge against commitment to a term more specific, e.g., fibrinoid instead of fibrin, nevoid rather than nevus, and “oid-oid disease” in lieu of exudative discoid and lichenoid chronic dermatosis (which is a circumlocution for and ev…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…es induce changes of small-vessel vasculitis as manifested by fibrin in the wall of venules, as shown here, thrombi in lumen of venules, or both of them together. 10.5.9A: Vesicular dermatitis, intraepidermal, spongiotic, ulcerated + 10.5.9…

Differential Diagnosis in Dermatopathology

Lupus erythematosus profundus vs. Panniculitis-like T-cell lymphoma

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…he reticular dermis or the subcutaneous fat 11. Deposits of fibrin at the periphery of fat lobules 11. No deposits of fibrin at the periphery of lobules 12. Findings diagnostic of discoid lupus erythematosus at the dermoepidermal junction in some…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

…t represents an anticipated physiologic response; deposits of fibrin beneath erosions and ulcerations because they are a consequence inevitably of whatever injury was responsible for those particular losses of tissue; degranulation of eosinophils in…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…