Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ust of neutrophils,” basophilia of collagen bundles, and fibrin at the tip of dermal papillae are present beneath and at the sides of a blister 5. No neutrophils, basophilia of collagen, or fibrin at the tip of dermal papillae at the sides of a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

“Pruritic urticarial papules and plaques of pregnancy (PUPPP) was recently defined as an intensely pruritic cutaneous eruption occurring in the third trimester. . . . The overall picture was nonspecific and ranged from one suggestive of eryt…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg

The patient A 61-year-old woman presented herself with a chronic and widespread eruption of erythematous papules, pustules, ulcers, and hyperpigmented scars (Figures 1A-E). She had a history of rheumatoid arthritis. Figures 1A-E. Clinical appeara…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

“The term necrotizing angiitis has proved to be a convenient generic term for the entire group of vascular lesions, both arterial and venous, in which the fully developed stage is characterized by fibrinoid necrosis and inflammation involving…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

…y as a hedge against commitment to a term more specific, e.g., fibrinoid instead of fibrin, nevoid rather than nevus, and “oid-oid disease” in lieu of exudative discoid and lichenoid chronic dermatosis (which is a circumlocution for and e…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.5.1A: Perivascular and interstitial dermatitis + 10.5.1B: Lymphocytes and eosinophils around venules, and neutrophils in the interstitium in conjunction with degeneration of bundles of collagen focally = Response to an arthropod…

Differential Diagnosis in Dermatopathology

Lupus erythematosus profundus vs. Panniculitis-like T-cell lymphoma

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…the reticular dermis or the subcutaneous fat 11. Deposits of fibrin at the periphery of fat lobules 11. No deposits of fibrin at the periphery of lobules 12. Findings diagnostic of discoid lupus erythematosus at the dermoepidermal junction in som…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

Certain basic concepts that pertain to the method recommended here for diagnosis of inflammatory diseases of the skin and subcutaneous fat deserve mention. First, it is advantageous to examine sections of tissue, from the very outset, without refere…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…