Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

“Eleven out of 17 presented with chilblain LE after the development of facial discoid LE and the delay varied from 1 to 14 years (mean 5.9 years). . . . Three patients had chilblains and bad circulation before the onset of LE. The sites of th…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg

The patient A 61-year-old woman presented herself with a chronic and widespread eruption of erythematous papules, pustules, ulcers, and hyperpigmented scars (Figures 1A-E). She had a history of rheumatoid arthritis. Figures 1A-E. Clinical appeara…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

“The term necrotizing angiitis has proved to be a convenient generic term for the entire group of vascular lesions, both arterial and venous, in which the fully developed stage is characterized by fibrinoid necrosis and inflammation involving…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

…y as a hedge against commitment to a term more specific, e.g., fibrinoid instead of fibrin, nevoid rather than nevus, and “oid-oid disease” in lieu of exudative discoid and lichenoid chronic dermatosis (which is a circumlocution for and e…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.5.1A: Perivascular and interstitial dermatitis + 10.5.1B: Lymphocytes and eosinophils around venules, and neutrophils in the interstitium in conjunction with degeneration of bundles of collagen focally = Response to an arthropod…

Differential Diagnosis in Dermatopathology

Lupus erythematosus profundus vs. Panniculitis-like T-cell lymphoma

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…the reticular dermis or the subcutaneous fat 11. Deposits of fibrin at the periphery of fat lobules 11. No deposits of fibrin at the periphery of lobules 12. Findings diagnostic of discoid lupus erythematosus at the dermoepidermal junction in som…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

Certain basic concepts that pertain to the method recommended here for diagnosis of inflammatory diseases of the skin and subcutaneous fat deserve mention. First, it is advantageous to examine sections of tissue, from the very outset, without refere…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

Leprosy Synonyms Hansen’s disease Lepra Presentation stereotypical Age and sex Young adults of both sexes who live in endemic areas Distribution of lesions Localized in indeterminate and tuberculoid types; widespread and symmetrical in lepro…