Histologic Diagnosis of Inflammatory Skin Diseases

Erythema elevatum diutinum

…cles of thin wiry bundles of collagen accompanied by numerous fibrocytes in the reticular dermis; fascicles often assume an interwoven pattern at sites where previously there had been nodular and/or diffuse mixed-cell infiltrates. Diffuse, but sparse…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s, plasma cells, neutrophils, and eosinophils in company with fibrocytes and histiocytes, the latter being predominant = Interstitial granulomatous dermatitis with arthritis Some histiocytes have abnormal nuclei and some of them are in mitosis. Histi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus?

…term is employed generally, may be melanocytes, keratocytes, fibrocytes, endothelial cells, or adipocytes. So-called nevus cells are abnormal melanocytes. To complicate the matter further is the curious word “nevoid.” If the designation…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

…of that fibrous protein. Collagen is a fiber and, unlike the fibrocytes that produce it, cannot undergo necrosis; only viable cells can suffer necrosis. The tinctorial and structural changes in collagen observed in necrobiosis lipoidica and in necro…

Differential Diagnosis in Dermatopathology

Discussions

…icular pattern in relationship to nearby oval histiocytes and fibrocytes, but are clustered, often in association with pools of serum. In an evolving dermatofibroma, extravasated erythrocytes may be present in a sheet. In contradistinction, even when…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermatofibroma?

…e stage the fibrosis is affiliated with a decreased number of fibrocytes in conjunction with “homogenization” of bundles of collagen (subepidermal nodular sclerosis). The red hue of a early lesion is a consequence of the proliferation of…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…reponderance of histiocytes, and ends with a near monopoly of fibrocytes that are responsible for striking fibrosis. In the process, the septa become widened markedly, and, concurrent, the lobules appear to be shrunken, at the same time that they, to…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…omaly elongate) 2. Collagen bundles arranged haphazardly 3. Fibrocytes normal cytologically not usually increased in number 3. Fibrocytes often large, stellate, or multinucleate are markedly increased in number 4. Collagen bundles thick and coar…