Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dysplasia?

…ocytic hyperplasia, atypical melanocytic hyperplasia, lamellar fibroplasia, concentric fibroplasias, and lymphocytic infiltrates, are also found in melanomas. In brief, their criteria do not permit differentiation of the benign and malignant neoplasm…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.28.1A: Vesicular dermatitis, subepidermal, mixed-cell + 10.28.1B: Scant infiltrate of neutrophils and eosinophils in the subepidermal space = Epidermolysis bullosa, recessive dystrophic The specimen can be told to have come from…

Histologic Diagnosis of Inflammatory Skin Diseases

Acquired epidermolysis bullosa

Acquired epidermolysis bullosa Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Predilection for skin above joints and at sites of trauma; oral lesions sometimes Individual lesions Vesicles, bullae, scars, and mili…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…12. Mucin in the stroma sometimes 12. No mucin 13. Diffuse fibroplasia 13. Fibroplasia around lobules of endothelial cells at the periphery of a lesion 14. Thickened bundles of collagen within the lesion itself, especially at the periphery of i…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.33.1A: Panniculitis, mostly septal + 10.33.1B: Neutrophils among tiny collections of histiocytes and clefts within those collections = Erythema nodosum These findings represent an early stage in the evolution of erythema nodosum…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Metastasizing Dermatofibroma?

“. . . We conclude that dermatofibromas can very rarely metastasize. Risk factors for metastasis may include relatively large size, high cellularity, and local recurrence. It would appear that metastasizing dermatofibromas behave in an indol…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

Incontinentia pigmenti Synonyms Bloch-Sulzberger syndrome Presentation stereotypical Age and sex Lesions in females at birth. Practically never in boys. Distribution of lesions Trunk and extremities Arrangement of lesions Linear, streaks, and whorls…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

“Nine biopsies revealed a distinctive type of fibroma characterized by an organized pattern of interwoven fascicles of collagen bundles with a laminated or tortuous appearance, embedded in abundant mucin. A number of fibromas showed striking…