Differential Diagnosis in Dermatopathology

Discussions

Darier’s disease and Grover’s disease have several findings histopathologic in common, among them foci of acantholytic dyskeratotic cells in the epidermis and a superficial perivascular infiltrate of inflammatory cells, usually lymphocyt…

Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

Darier’s disease and simulators of it Synonyms Darier-White disease Presentation stereotypical Age and sex Onset in childhood or adolescence in both sexes Distribution of lesions Symmetrical and widespread, favoring the neck, shoulders, upper…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Lichen planus-like keratosis Solar keratosis with lichenoid infiltrate of lymphocytes 1. Crusts often 1. No crusts in non-traumatized lesions 2. Ortho- and parakeratosis not arranged in discrete columns 2. Ortho- and parakeratosis alternate wi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.44.1A: Perivascular dermatitis, sparse + 10.44.1B: A suprabasal cleft, acanthotic dyskeratotic cells in the spinous and granular zones, and a column of parakeratosis = Grover’s disease Changes in foci of the epidermis iden…

Dermatology Practical & Conceptual

Pigmented Lesions

Non-melanocytic lesions Inflammatory Post-inflammatory hyperpigmentation¬†(523, 649) Melanophages in number variable scattered in the papillary dermis, rarely in the upper part of the reticular dermis too. Melanin increased in amount in the epi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Radial Growth Phase versus Vertical Growth Phase of Melanoma?

…rnity of “vertical growth phase,” or where a solar keratosis ends and a squamous-cell carcinoma begins; solar keratosis is a superficial squamous-cell carcinoma. These exercises not only are futile, but they also deter histopathologists f…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

“On the basis of clinical, histological, and cellular kinetic observations, a separation of the major ichthyosiform dermatoses into four groups is proposed. Ichthyosis vulgaris patients have dry skin and fine scales on their trunk and extremi…

Dermatology Practical & Conceptual

Pseudofolliculitis barbae: a dermatoscopic correlate

Report of a case A 45-year-old man presented with a slightly tender rash on his face of about three months’ duration. Past medical history was non-contributory. Physical examination revealed a solitary 1 cm erythematous nodule in the right sub…