Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…benign neoplasms (two examples already cited being seborrheic keratosis, especially in the form of lichen planus-like keratosis, and a particular melanocytic nevus in the form of halo nevus) are associated with dense infiltrates of inflammatory cells…

Differential Diagnosis in Dermatopathology

Discussions

…se, which is an inflammatory process. Darier’s disease (keratosis follicularis) is a genodermatosis inherited in autosomal-dominant fashion and is not fundamentally an inflammatory disease. The lesions usually appear during the second decade of…

Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

…one, thickened in zones above suprabasal clefts Column of parakeratosis positioned above acantholytic, dyskeratotic cells that reside above a suprabasal cleft Correlation clinicopathologic The keratotic component of papules of Darier’s disease…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Lichen planus-like keratosis Solar keratosis with lichenoid infiltrate of lymphocytes 1. Crusts often 1. No crusts in non-traumatized lesions 2. Ortho- and parakeratosis not arranged in discrete columns 2. Ortho- and parakeratosis alternate wi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…cells in the spinous and granular zones, and a column of parakeratosis = Grover’s disease Changes in foci of the epidermis identical with those pictured here may be found in Darier’s disease and in a type of epidermal nevus that sports f…

Dermatology Practical & Conceptual

Pigmented Lesions

…l. Slight increase of melanin in the epidermis. Nevoid hyperkeratosis of the nipple¬†(443) Broad mammillations, each formed by a subtly elevated dermal papilla, interrupted by thin epidermal rete ridges pigmented markedly. Hemorrhage Ungual and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Radial Growth Phase versus Vertical Growth Phase of Melanoma?

…nity of “vertical growth phase,” or where a solar keratosis ends and a squamous-cell carcinoma begins; solar keratosis is a superficial squamous-cell carcinoma. These exercises not only are futile, but they also deter histopathologists fr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…ular layer is prominent in this condition. Epidermolytic hyperkeratosis consists of a clinical spectrum of disorders; generalized forms may be bullous, and localized forms may resemble linear nevi. Intracellular and intercellular edema gives the epid…

Dermatology Practical & Conceptual

Pseudofolliculitis barbae: a dermatoscopic correlate

…ed lines. Thick curved lines are typically seen in seborrheic keratosis. The gray and blue colors are consistent with melanin contained within the pigmented hair shaft in the dermis. According to current understanding, collagen fibrils that are prese…